3qu6: Difference between revisions

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-{{STRUCTURE_3qu6|  PDB=3qu6  |  SCENE=  }}
-===Crystal structure of IRF-3 DBD free form===
-{{ABSTRACT_PUBMED_21596780}}
-==About this Structure==
+==Crystal structure of IRF-3 DBD free form==
-[[3qu6]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QU6 OCA].
+<StructureSection load='3qu6' size='340' side='right'caption='[[3qu6]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[3qu6]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QU6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QU6 FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qu6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qu6 OCA], [https://pdbe.org/3qu6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qu6 RCSB], [https://www.ebi.ac.uk/pdbsum/3qu6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qu6 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/IRF3_HUMAN IRF3_HUMAN] Key transcriptional regulator of type I interferon (IFN)-dependent immune responses and plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, becomes phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes. Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in primary macrophages.
 ==See Also==
 *[[Interferon regulatory factor|Interferon regulatory factor]]
+__TOC__
-==Reference==
+</StructureSection>
-<ref group="xtra">PMID:021596780</ref><references group="xtra"/>
 [[Category: Homo sapiens]]
-[[Category: Aggarwal, A K.]]
+[[Category: Large Structures]]
-[[Category: Escalante, C R.]]
+[[Category: Aggarwal AK]]
-[[Category: Ioannes, P E.De.]]
+[[Category: De Ioannes PE]]
-[[Category: Dna binding protein]]
+[[Category: Escalante CR]]
-[[Category: Gene regulation]]
-[[Category: Helix-turn-helix]]