3qq6: Difference between revisions

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==The N-terminal DNA binding domain of SinR from Bacillus subtilis==
The line below this paragraph, containing "STRUCTURE_3qq6", creates the "Structure Box" on the page.
<StructureSection load='3qq6' size='340' side='right'caption='[[3qq6]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3qq6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QQ6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QQ6 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qq6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qq6 OCA], [https://pdbe.org/3qq6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qq6 RCSB], [https://www.ebi.ac.uk/pdbsum/3qq6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qq6 ProSAT]</span></td></tr>
{{STRUCTURE_3qq6|  PDB=3qq6  |  SCENE=  }}
</table>
 
== Function ==
===The N-terminal DNA binding domain of SinR from Bacillus subtilis===
[https://www.uniprot.org/uniprot/SINR_BACSU SINR_BACSU] Negative as well as positive regulator of alternate developmental processes that are induced at the end of vegetative growth in response to nutrient depletion. Binds to the alkaline protease (aprE) gene at two sites. Also acts as a repressor of the key sporulation gene spo0A. Negatively regulates transcription of the eps operon, which is responsible for the biosynthesis of an exopolysaccharide involved in biofilm formation; therefore it could govern the transition between a state in which bacteria swim or swarm and a state in which bacteria assemble into multicellular communities. Acts with Hpr as a corepressor of epr expression. Also negatively regulates transcription of the lutABC operon, which is required for lactate utilization. Repressor activity is regulated by SinI.<ref>PMID:1898931</ref> <ref>PMID:7642487</ref> <ref>PMID:15661000</ref> <ref>PMID:16923912</ref>
 
== References ==
 
<references/>
==About this Structure==
__TOC__
[[3qq6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QQ6 OCA].  
</StructureSection>
[[Category: Bacillus subtilis]]
[[Category: Bacillus subtilis]]
[[Category: Colledge, V.]]
[[Category: Large Structures]]
[[Category: Dodson, E J.]]
[[Category: Colledge V]]
[[Category: Fogg, M J.]]
[[Category: Dodson EJ]]
[[Category: Levdikov, V M.]]
[[Category: Fogg MJ]]
[[Category: Wilkinson, A J.]]
[[Category: Levdikov VM]]
[[Category: Biofilm]]
[[Category: Wilkinson AJ]]
[[Category: Helix-turn-helix motif]]
[[Category: Repressor]]
[[Category: Sini]]
[[Category: Transcription]]
[[Category: Transcriptional regulator]]

Latest revision as of 14:54, 14 March 2024

The N-terminal DNA binding domain of SinR from Bacillus subtilisThe N-terminal DNA binding domain of SinR from Bacillus subtilis

Structural highlights

3qq6 is a 2 chain structure with sequence from Bacillus subtilis. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.9Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

SINR_BACSU Negative as well as positive regulator of alternate developmental processes that are induced at the end of vegetative growth in response to nutrient depletion. Binds to the alkaline protease (aprE) gene at two sites. Also acts as a repressor of the key sporulation gene spo0A. Negatively regulates transcription of the eps operon, which is responsible for the biosynthesis of an exopolysaccharide involved in biofilm formation; therefore it could govern the transition between a state in which bacteria swim or swarm and a state in which bacteria assemble into multicellular communities. Acts with Hpr as a corepressor of epr expression. Also negatively regulates transcription of the lutABC operon, which is required for lactate utilization. Repressor activity is regulated by SinI.[1] [2] [3] [4]

References

  1. ↑ Gaur NK, Oppenheim J, Smith I. The Bacillus subtilis sin gene, a regulator of alternate developmental processes, codes for a DNA-binding protein. J Bacteriol. 1991 Jan;173(2):678-86. PMID:1898931
  2. ↑ Mandic-Mulec I, Doukhan L, Smith I. The Bacillus subtilis SinR protein is a repressor of the key sporulation gene spo0A. J Bacteriol. 1995 Aug;177(16):4619-27. PMID:7642487
  3. ↑ Kearns DB, Chu F, Branda SS, Kolter R, Losick R. A master regulator for biofilm formation by Bacillus subtilis. Mol Microbiol. 2005 Feb;55(3):739-49. PMID:15661000 doi:10.1111/j.1365-2958.2004.04440.x
  4. ↑ Kodgire P, Dixit M, Rao KK. ScoC and SinR negatively regulate epr by corepression in Bacillus subtilis. J Bacteriol. 2006 Sep;188(17):6425-8. PMID:16923912 doi:10.1128/JB.00427-06

3qq6, resolution 1.90Å

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