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== | ==Candida albicans dihydrofolate reductase complexed with NADPH and 5-[3-(2,5-dimethoxyphenyl)prop-1-yn-1-yl]-6-ethylpyrimidine-2,4-diamine (UCP120B)== | ||
[[3qlw]] is a 2 chain structure with sequence from [ | <StructureSection load='3qlw' size='340' side='right'caption='[[3qlw]], [[Resolution|resolution]] 2.50Å' scene=''> | ||
== Structural highlights == | |||
== | <table><tr><td colspan='2'>[[3qlw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Candida_albicans Candida albicans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QLW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QLW FirstGlance]. <br> | ||
< | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.504Å</td></tr> | ||
[ | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=N22:5-[3-(2,5-DIMETHOXYPHENYL)PROP-1-YN-1-YL]-6-ETHYLPYRIMIDINE-2,4-DIAMINE'>N22</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr> | ||
[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qlw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qlw OCA], [https://pdbe.org/3qlw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qlw RCSB], [https://www.ebi.ac.uk/pdbsum/3qlw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qlw ProSAT]</span></td></tr> | ||
[ | </table> | ||
[ | == Function == | ||
[ | [https://www.uniprot.org/uniprot/DYR_CANAX DYR_CANAX] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | ||
[ | __TOC__ | ||
[ | </StructureSection> | ||
[[Category: Candida albicans]] | |||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Anderson AC]] | ||
[[Category: | [[Category: Bendel SD]] | ||
[[Category: | [[Category: Paulsen JL]] | ||
[[Category: | |||
Latest revision as of 14:50, 14 March 2024
Candida albicans dihydrofolate reductase complexed with NADPH and 5-[3-(2,5-dimethoxyphenyl)prop-1-yn-1-yl]-6-ethylpyrimidine-2,4-diamine (UCP120B)Candida albicans dihydrofolate reductase complexed with NADPH and 5-[3-(2,5-dimethoxyphenyl)prop-1-yn-1-yl]-6-ethylpyrimidine-2,4-diamine (UCP120B)
Structural highlights
FunctionDYR_CANAX Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. |
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