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==Crystal structure of human beta-crystallin B3==
==Crystal structure of human beta-crystallin B3==
<StructureSection load='3qk3' size='340' side='right' caption='[[3qk3]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
<StructureSection load='3qk3' size='340' side='right'caption='[[3qk3]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3qk3]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QK3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QK3 FirstGlance]. <br>
<table><tr><td colspan='2'>[[3qk3]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QK3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QK3 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CRYBB3, CRYB3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qk3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qk3 OCA], [http://pdbe.org/3qk3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3qk3 RCSB], [http://www.ebi.ac.uk/pdbsum/3qk3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3qk3 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qk3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qk3 OCA], [https://pdbe.org/3qk3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qk3 RCSB], [https://www.ebi.ac.uk/pdbsum/3qk3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qk3 ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
[[http://www.uniprot.org/uniprot/CRBB3_HUMAN CRBB3_HUMAN]] Non-syndromic congenital cataract. Cataract, congenital, nuclear, autosomal recessive 2 (CATCN2) [MIM:[http://omim.org/entry/609741 609741]]: A congenital cataract affecting the central nucleus of the eye. Nucler cataracts are often not highly visually significant. The density of the opacities varies greatly from fine dots to a dense, white and chalk-like, central cataract. The condition is usually bilateral. Nuclear cataracts are often combined with opacified cortical fibers encircling the nuclear opacity, which are referred to as cortical riders. Note=The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:15914629</ref>
[https://www.uniprot.org/uniprot/CRBB3_HUMAN CRBB3_HUMAN] Non-syndromic congenital cataract. Cataract, congenital, nuclear, autosomal recessive 2 (CATCN2) [MIM:[https://omim.org/entry/609741 609741]: A congenital cataract affecting the central nucleus of the eye. Nucler cataracts are often not highly visually significant. The density of the opacities varies greatly from fine dots to a dense, white and chalk-like, central cataract. The condition is usually bilateral. Nuclear cataracts are often combined with opacified cortical fibers encircling the nuclear opacity, which are referred to as cortical riders. Note=The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:15914629</ref>  
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/CRBB3_HUMAN CRBB3_HUMAN]] Crystallins are the dominant structural components of the vertebrate eye lens.  
[https://www.uniprot.org/uniprot/CRBB3_HUMAN CRBB3_HUMAN] Crystallins are the dominant structural components of the vertebrate eye lens.
 
==See Also==
*[[Crystallin 3D structures|Crystallin 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Arrowsmith, C H]]
[[Category: Large Structures]]
[[Category: Bountra, C]]
[[Category: Arrowsmith CH]]
[[Category: Cocking, R]]
[[Category: Bountra C]]
[[Category: Delft, F von]]
[[Category: Cocking R]]
[[Category: Edwards, A]]
[[Category: Edwards A]]
[[Category: Gileadi, C]]
[[Category: Gileadi C]]
[[Category: Kavanagh, K]]
[[Category: Kavanagh K]]
[[Category: Krojer, T]]
[[Category: Krojer T]]
[[Category: Muniz, J]]
[[Category: Muniz J]]
[[Category: Oppermann, U]]
[[Category: Oppermann U]]
[[Category: Pike, A C.W]]
[[Category: Pike ACW]]
[[Category: Pilka, E]]
[[Category: Pilka E]]
[[Category: Structural genomic]]
[[Category: Vollmar M]]
[[Category: Vollmar, M]]
[[Category: Weigelt J]]
[[Category: Weigelt, J]]
[[Category: Yue WW]]
[[Category: Yue, W W]]
[[Category: Von Delft F]]
[[Category: Beta b3]]
[[Category: Cataract]]
[[Category: Crybb3]]
[[Category: Crystallin]]
[[Category: Eye lens protein]]
[[Category: Sgc]]
[[Category: Structural protein]]

Latest revision as of 14:48, 14 March 2024

Crystal structure of human beta-crystallin B3Crystal structure of human beta-crystallin B3

Structural highlights

3qk3 is a 3 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.95Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

CRBB3_HUMAN Non-syndromic congenital cataract. Cataract, congenital, nuclear, autosomal recessive 2 (CATCN2) [MIM:609741: A congenital cataract affecting the central nucleus of the eye. Nucler cataracts are often not highly visually significant. The density of the opacities varies greatly from fine dots to a dense, white and chalk-like, central cataract. The condition is usually bilateral. Nuclear cataracts are often combined with opacified cortical fibers encircling the nuclear opacity, which are referred to as cortical riders. Note=The disease is caused by mutations affecting the gene represented in this entry.[1]

Function

CRBB3_HUMAN Crystallins are the dominant structural components of the vertebrate eye lens.

See Also

References

  1. ↑ Riazuddin SA, Yasmeen A, Yao W, Sergeev YV, Zhang Q, Zulfiqar F, Riaz A, Riazuddin S, Hejtmancik JF. Mutations in betaB3-crystallin associated with autosomal recessive cataract in two Pakistani families. Invest Ophthalmol Vis Sci. 2005 Jun;46(6):2100-6. PMID:15914629 doi:46/6/2100

3qk3, resolution 1.95Å

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