3qi2: Difference between revisions

← Older edit

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 3qi2 is ON HOLD
+==A Galpha P-loop mutation prevents transition to the activated state: G42R bound to RGS14 GoLoco==
+<StructureSection load='3qi2' size='340' side='right'caption='[[3qi2]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
-Authors: Bosch, D.E., Willard, F.S., Kimple, A.J., Miley, M.J., Siderovski, D.P.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[3qi2]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QI2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QI2 FirstGlance]. <br>
-Description: A Galpha P-loop mutation prevents transition to the activated state: G42R bound to RGS14 GoLoco
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.797&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qi2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qi2 OCA], [https://pdbe.org/3qi2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qi2 RCSB], [https://www.ebi.ac.uk/pdbsum/3qi2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qi2 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/GNAI1_HUMAN GNAI1_HUMAN] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.<ref>PMID:17635935</ref> <ref>PMID:17264214</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Bosch DE]]
+[[Category: Kimple AJ]]
+[[Category: Miley MJ]]
+[[Category: Siderovski DP]]
+[[Category: Willard FS]]