3qbv: Difference between revisions

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-[[Image:3qbv.png|left|200px]]
-<!--
+==Structure of designed orthogonal interaction between CDC42 and nucleotide exchange domains of intersectin==
-The line below this paragraph, containing "STRUCTURE_3qbv", creates the "Structure Box" on the page.
+<StructureSection load='3qbv' size='340' side='right'caption='[[3qbv]], [[Resolution|resolution]] 2.65&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[3qbv]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QBV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QBV FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.65&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene></td></tr>
-{{STRUCTURE_3qbv|  PDB=3qbv  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qbv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qbv OCA], [https://pdbe.org/3qbv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qbv RCSB], [https://www.ebi.ac.uk/pdbsum/3qbv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qbv ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/CDC42_HUMAN CDC42_HUMAN] Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Plays a role in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. Mediates CDC42-dependent cell migration.<ref>PMID:14978216</ref> <ref>PMID:15642749</ref> <ref>PMID:17038317</ref>
-===Structure of designed orthogonal interaction between CDC42 and nucleotide exchange domains of intersectin===
+==See Also==
+*[[GTP-binding protein 3D structures|GTP-binding protein 3D structures]]
+*[[Intersectin|Intersectin]]
-<!--
+== References ==
-The line below this paragraph, {{ABSTRACT_PUBMED_22403064}}, adds the Publication Abstract to the page
+<references/>
-(as it appears on PubMed at http://www.pubmed.gov), where 22403064 is the PubMed ID number.
+__TOC__
--->
+</StructureSection>
-{{ABSTRACT_PUBMED_22403064}}
-==About this Structure==
-[[3qbv]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QBV OCA].
-==Reference==
-<ref group="xtra">PMID:022403064</ref><references group="xtra"/>
 [[Category: Homo sapiens]]
-[[Category: Kapp, G T.]]
+[[Category: Large Structures]]
-[[Category: Kortemme, T.]]
+[[Category: Kapp GT]]
-[[Category: Lim, W A.]]
+[[Category: Kortemme T]]
-[[Category: Remenyi, A.]]
+[[Category: Lim WA]]
-[[Category: Cell junction]]
+[[Category: Remenyi A]]
-[[Category: Cell membrane]]
-[[Category: Cell projection]]
-[[Category: Computationally designed]]
-[[Category: Endocytosis]]
-[[Category: Gtp-binding]]
-[[Category: Gtpase]]
-[[Category: Lipoprotein]]
-[[Category: Membrane]]
-[[Category: Methylation]]
-[[Category: Nucleotide exchange]]
-[[Category: Nucleotide-binding]]
-[[Category: Orthogonal interaction]]
-[[Category: Phosphoprotein]]
-[[Category: Prenylation]]
-[[Category: Protein binding-signaling protein complex]]
-[[Category: Sh3 domain]]
-[[Category: Synapse]]
-[[Category: Synaptosome]]