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New page: == 3D Structures of urokinase == Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} {{#tree:id=OrganizedByTopic|openlevels=0| *Urokinase **2i9a - hUK Hc N ...
 
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== 3D Structures of urokinase ==
== 3D Structures of urokinase ==


Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} - For a general description of the protein see [[Urokinase]]
{{#tree:id=OrganizedByTopic|openlevels=0|
{{#tree:id=OrganizedByTopic|openlevels=0|


*Urokinase
*Urokinase; Domains - N terminal 21-163; Kringle 69-153; catalytic 179-431


**[[2i9a]] - hUK Hc N terminal (residues 21-163) - human<br />
**[[2i9a]] - hUK Hc N terminal - human<br />
**[[1urk]] - hUK Hc N terminal – NMR<br />
**[[1urk]] - hUK Hc N terminal – NMR<br />
**[[1kdu]] – hUK kringle domain (residues 69-153) - NMR<br />
**[[1kdu]] – hUK kringle domain - NMR<br />
**[[4dva]] – hUK catalytic domain (residues 179-431) <br />
**[[4dva]] – hUK catalytic domain <br />
**[[4xsk]] - hUK  catalytic domain (mutant) <br />
**[[4xsk]], [[5za7]], [[2o8t]] - hUK  catalytic domain (mutant) <br />
**[[5lhs]] - UK  catalytic domain (mutant) - mouse<br />
**[[5lhs]] - UK  catalytic domain (mutant) - mouse<br />


*Urokinase catalytic domain 179-424 complex with inhibitors
*Urokinase catalytic domain complex with inhibitors


**[[4fu7]], [[4fu8]], [[4fu9]], [[4fub]], [[5xg4]], [[5wxs]] - hUK + inhibitor<br />
****[[1c5l]], [[1c5m]], [[1c5n]], [[1c5o]], [[1c5p]], [[1c5q]], [[1c5r]], [[1c5s]], [[1c5t]], [[1c5u]], [[1c5v]], [[1c5w]], [[1c5x]], [[1c5y]], [[1c5z]], [[3ig6]], [[4fu7]], [[4fu8]], [[4fu9]], [[4fub]] - hUK + inhibitor<br />
**[[1f92]], [[1sc8]], [[1vj9]], [[1vja]], [[2o8t]], [[2o8u]], [[2o8w]], [[4h42]], [[4mnv]],[[5wxt]] - hUK (mutant) + inhibitor<br />
**[[1f92]], [[1gj7]], [[1gj8]], [[1gj9]], [[1gja]], [[1gjd]], [[1o5a]], [[1o5b]], [[1sc8]], [[1vj9]], [[1vja]], [[3kgp]], [[3khv]], [[3kid]], [[3mhw]], [[3mwi]], [[4h42]], [[5wxs]], [[5wxt]] - hUK (mutant) + inhibitor<br />
**[[1fv9]] – hUK (mutant) + benzimidazole derivative <br />
**[[6ag7]] - hUK + pyrazine inhibitor<br />
**[[5yc6]], [[5yc7]] - hUK  (mutant) + benzylamine derivative<br />
**[[5za8]], [[5za9]], [[5zae]], [[5zaf]], [[5zag]], [[5zah]], [[5zaj]], [[5zc5]], [[6ag2]], [[6ag3]], [[6ag9]], [[6jyp]], [[6jyq]], [[6l04]], [[6l05]] - hUK (mutant) + pyrazine inhibitor<br />
**[[1f5k]] - hUK (mutant) + benzamidine derivative<br />
**[[1fv9]], [[1gi7]], [[1gi8]], [[1gi9]], [[1gjb]], [[1gjc]], [[1o3p]], [[1o5c]] – hUK (mutant) + benzimidazole derivative <br />
**[[5yc6]], [[5yc7]], [[5z1c]] - hUK  (mutant) + benzylamine derivative<br />
**[[1f5k]], [[2o8u]], [[6ag2]], [[6ag3]] - hUK (mutant) + benzamidine derivative<br />
**[[1f5l]] - hUK (mutant) + amiloride derivative<br />
**[[1f5l]] - hUK (mutant) + amiloride derivative<br />
**[[1owd]], [[1owe]], [[1owh]], [[1owi]], [[1owj]], [[1owk]], [[1sqa]], [[1sqo]], [[1u6q]], [[1sqt]], [[4fuc]], [[4fud]], [[4fue]], [[4fuf]], [[4fug]], [[4fuh]], [[4fui]], [[4fuj]]- hUK + naphthamidine inhibitor<br />
**[[1owd]], [[1owe]], [[1owh]], [[1owi]], [[1owj]], [[1owk]], [[1sqa]], [[1sqo]], [[1u6q]], [[1sqt]], [[4fuc]], [[4fud]], [[4fue]], [[4fuf]], [[4fug]], [[4fuh]], [[4fui]], [[4fuj]], [[7vm6]] - hUK + naphthamidine inhibitor<br />
**[[6nmb]]- hUK + tranexamic acid inhibitor<br />
**[[6nmb]]- hUK + tranexamic acid inhibitor<br />
**[[1ejn]] - hUK (mutant) + urea derivative inhibitor<br />
**[[1ejn]] - hUK (mutant) + urea derivative inhibitor<br />
**[[2vin]], [[2vio]], [[2vip]], [[2viq]], [[2viv]], [[2viw]] - hUK (mutant) + mexiletine derivative<br />
**[[2vin]], [[2vio]], [[2vip]], [[2viq]], [[2viv]], [[2viw]] - hUK (mutant) + mexiletine derivative<br />
**[[3qn7]], [[4jk5]], [[4jk6]], [[4x1n]], [[4x1q]], [[4x1r]], [[4x1s]], [[4x0w]], [[4x1p]], [[4zhl]], [[4zhm]], [[4zkn]], [[4zko]], [[4zkr]], [[4zks]] - hUK (mutant) + peptide inhibitor<br />
**[[6xvd]], [[1lmw]] - hUK + peptide inhibitor<br />
**[[4mnw]], [[4mnx]], [[4mny]], [[4os1]], [[4os2]], [[4os4]], [[4os5]], [[4os6]], [[4os7]] - hUK (mutant) + bicyclic peptide <br />
**[[3ox7]], [[3oy5]], [[3oy6]], [[3qn7]], [[4jk5]], [[4jk6]], [[4x1n]], [[4x1q]], [[4x1r]], [[4x1s]], [[4x0w]], [[4x1p]], [[4zhl]], [[4zhm]], [[4zkn]], [[4zko]], [[4zkr]], [[4zks]], [[5wxo]], [[5wxp]], [[5wxq]], [[5wxr]], [[5wxf]] - hUK (mutant) + peptide inhibitor<br />
**[[2vnt]], [[2r2w]] - hUK + guanidine derivative<br />
**[[7zrr]], [[7zrt]] - hUK + bicyclic peptide <br />
**[[2nwn]], [[3m61]], [[4gly]], [[4mnw]], [[4mnv]], [[4mnx]], [[4mny]], [[4os1]], [[4os2]], [[4os4]], [[4os5]], [[4os6]], [[4os7]] - hUK (mutant) + bicyclic peptide <br />
**[[6xvd]] - hUK  catalytic domain + upain-1 peptide<br />
**[[2o8w]], [[2vnt]], [[2r2w]], [[7vm5]] - hUK + guanidine derivative<br />
**[[5xg4]] - hUK + quercetin<br />
**[[5xg4]] - hUK + quercetin<br />
**[[1w0z]], [[1w10]], [[1w11]], [[1w12]], [[1w13]], [[1w14]] - hUK + alanineamide derivative<br />
**[[1w0z]], [[1w10]], [[1w11]], [[1w12]], [[1w13]], [[1w14]] - hUK + alanineamide derivative<br />
**[[6xvd]]- hUK + UPAIN-1-W3F<br />
**[[7dzd]], [[7vm4]], [[7vm7]] - hUK + drug<br />
**[[5wxf]]- hUK + UPAIN-2<br />
**[[6a8g]], [[6a8n]] - mUK (mutant) + cyclic peptide <br />
**[[5wxo]]- hUK + UPAIN-2-W3F<br />
**[[5wxp]]- hUK + UPAIN-2-3-W3F<br />
**[[5wxr]]- hUK + UPAIN-2-4-W3F<br />
 
*Urokinase C terminal complex with inhibitors
 
**[[3kgp]] – hUK Hc C terminal (mutant) + benzoic acid derivative<br />
**[[3khv]] - hUK Hc C terminal (mutant) + methanol derivative<br />
**[[3mwi]] - hUK Hc C terminal (mutant) + amidine derivative<br />
**[[3ox7]], [[3oy5]], [[3oy6]] - hUK Hc C terminal (mutant) + peptide inhibitor<br />
**[[3kid]], [[3mhw]] - hUK Hc C terminal (mutant) + aminobenzothiazole  derivative<br />
**[[2nwn]], [[4gly]] - hUK Hc C terminal + cyclic peptide<br />
**[[3m61]] - hUK Hc C terminal (mutant) + cyclic peptide
 
*Urokinase short chain + catalytic domain complex with inhibitors
 
**[[1lmw]] – hUK A+B catalytic domain + EGRCMK<br />
**[[1c5w]], [[1c5x]], [[1c5y]], [[1c5z]] - hUK A+B chain catalytic domain + carboxamidine derivative<br />
**[[1gi7]], [[1gi8]], [[1gi9]], [[1gj7]], [[1gj8]], [[1gj9]], [[1gja]], [[1gjb]], [[1gjc]], [[1gjd]] - hUK A+B chain catalytic domain (mutant) + carboxamidine derivative<br />
**[[1o3p]], [[1o5a]], [[1o5b]], [[1o5c]] - hUK A+B chain catalytic domain (mutant) + benzenolate derivative<br />
**[[3ig6]] – hUK A+B chain catalytic domain + inhibitor<br />


*Urokinase complex with protein
*Urokinase complex with protein
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**[[3laq]], [[3u73]] - hUK Hc N terminal + UK receptor<br />
**[[3laq]], [[3u73]] - hUK Hc N terminal + UK receptor<br />
**[[2i9b]] - hUK Hc N terminal + UK receptor (mutant)<br />
**[[2i9b]] - hUK Hc N terminal + UK receptor (mutant)<br />
**[[3pb1]] - hUK Hc C terminal (mutant) + UK inhibitor<br />
**[[3pb1]] - hUK Hc catalytic domain (mutant) + UK inhibitor<br />
**[[4dw2]] - hUK B chain catalytic domain + antibody<br />
**[[4dw2]] - hUK B chain catalytic domain + antibody<br />
**[[5hgg]] - hUK  catalytic domain (mutant) + antibody<br />
**[[5hgg]] - hUK  catalytic domain (mutant) + antibody<br />

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Michal Harel
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