1d3k: Difference between revisions

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OCA

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-{{Seed}}
-[[Image:1d3k.png|left|200px]]
-<!--
+==HUMAN SERUM TRANSFERRIN==
-The line below this paragraph, containing "STRUCTURE_1d3k", creates the "Structure Box" on the page.
+<StructureSection load='1d3k' size='340' side='right'caption='[[1d3k]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1d3k]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D3K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1D3K FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO3:CARBONATE+ION'>CO3</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene></td></tr>
-{{STRUCTURE_1d3k|  PDB=1d3k  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1d3k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1d3k OCA], [https://pdbe.org/1d3k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1d3k RCSB], [https://www.ebi.ac.uk/pdbsum/1d3k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1d3k ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/TRFE_HUMAN TRFE_HUMAN] Defects in TF are the cause of atransferrinemia (ATRAF) [MIM:[https://omim.org/entry/209300 209300]. Atransferrinemia is rare autosomal recessive disorder characterized by iron overload and hypochromic anemia.<ref>PMID:11110675</ref> <ref>PMID:15466165</ref>
+== Function ==
+[https://www.uniprot.org/uniprot/TRFE_HUMAN TRFE_HUMAN] Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/d3/1d3k_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1d3k ConSurf].
+<div style="clear:both"></div>
-===HUMAN SERUM TRANSFERRIN===
+==See Also==
+*[[Transferrin 3D structures|Transferrin 3D structures]]
+== References ==
-<!--
+<references/>
-The line below this paragraph, {{ABSTRACT_PUBMED_10739246}}, adds the Publication Abstract to the page
+__TOC__
-(as it appears on PubMed at http://www.pubmed.gov), where 10739246 is the PubMed ID number.
+</StructureSection>
--->
-{{ABSTRACT_PUBMED_10739246}}
-==About this Structure==
-D3K is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D3K OCA].
-==Reference==
-<ref group="xtra">PMID:10739246</ref><references group="xtra"/>
 [[Category: Homo sapiens]]
-[[Category: Brayer, G D.]]
+[[Category: Large Structures]]
-[[Category: Chen, J.]]
+[[Category: Brayer GD]]
-[[Category: Luo, Y.]]
+[[Category: Chen J]]
-[[Category: MacGillivray, R T.A.]]
+[[Category: Luo Y]]
-[[Category: Mason, A.]]
+[[Category: MacGillivray RTA]]
-[[Category: Murphy, M E.P.]]
+[[Category: Mason A]]
-[[Category: Wang, Y.]]
+[[Category: Murphy MEP]]
-[[Category: Woodworth, R C.]]
+[[Category: Wang Y]]
-[[Category: Yang, H W.]]
+[[Category: Woodworth RC]]
-[[Category: Carbonate]]
+[[Category: Yang H-W]]
-[[Category: Glycoprotein]]
-[[Category: Iron transport]]
-[[Category: Iron-release]]
-[[Category: Nlobe]]
-[[Category: Transferrin]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 23:27:20 2009''