1cvo: Difference between revisions

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-[[Image:1cvo.png|left|200px]]
-<!--
+==THE SOLUTION STRUCTURE OF CARDIOTOXIN V FROM NAJA NAJA ATRA==
-The line below this paragraph, containing "STRUCTURE_1cvo", creates the "Structure Box" on the page.
+<StructureSection load='1cvo' size='340' side='right'caption='[[1cvo]]' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1cvo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Naja_atra Naja atra]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CVO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CVO FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1cvo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cvo OCA], [https://pdbe.org/1cvo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1cvo RCSB], [https://www.ebi.ac.uk/pdbsum/1cvo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1cvo ProSAT]</span></td></tr>
-{{STRUCTURE_1cvo|  PDB=1cvo  |  SCENE=  }}
+</table>
+== Function ==
-===THE SOLUTION STRUCTURE OF CARDIOTOXIN V FROM NAJA NAJA ATRA===
+[https://www.uniprot.org/uniprot/3SOF5_NAJAT 3SOF5_NAJAT] Non-cytotoxic protein that does not show lytic and hemolytic activities, but can induce aggregation and fusion of sphingomyelin vesicles (PubMed:8182052). It binds to integrin alpha-V/beta-3 (ITGAV/ITGB3) with high affinity, and it inhibits osteoclast differentiation and bone resorption in mice, probably due to binding to integrin alpha-V/beta-3 (PubMed:16407244).<ref>PMID:14743531</ref> <ref>PMID:16407244</ref> <ref>PMID:8182052</ref> <ref>PMID:8703922</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
-<!--
+Check<jmol>
-The line below this paragraph, {{ABSTRACT_PUBMED_8347605}}, adds the Publication Abstract to the page
+  <jmolCheckbox>
-(as it appears on PubMed at http://www.pubmed.gov), where 8347605 is the PubMed ID number.
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cv/1cvo_consurf.spt"</scriptWhenChecked>
--->
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
-{{ABSTRACT_PUBMED_8347605}}
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
-==About this Structure==
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1cvo ConSurf].
-[[1cvo]] is a 1 chain structure of [[Cardiotoxin]] with sequence from [http://en.wikipedia.org/wiki/Naja_atra Naja atra]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CVO OCA].
+<div style="clear:both"></div>
 ==See Also==
-*[[Cardiotoxin]]
+*[[Cardiotoxin 3D structures|Cardiotoxin 3D structures]]
+== References ==
-==Reference==
+<references/>
-<ref group="xtra">PMID:8347605</ref><references group="xtra"/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
 [[Category: Naja atra]]
-[[Category: Chien, K Y.]]
+[[Category: Chien K-Y]]
-[[Category: Rule, G S.]]
+[[Category: Rule GS]]
-[[Category: Singhal, A K.]]
+[[Category: Singhal AK]]
-[[Category: Wu, W G.]]
+[[Category: Wu W-G]]
-[[Category: Cytotoxin]]