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[[Image:1cs8.jpg|left|200px]]


{{Structure
==CRYSTAL STRUCTURE OF PROCATHEPSIN L==
|PDB= 1cs8 |SIZE=350|CAPTION= <scene name='initialview01'>1cs8</scene>, resolution 1.8&Aring;
<StructureSection load='1cs8' size='340' side='right'caption='[[1cs8]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=OCS:CYSTEINESULFONIC+ACID'>OCS</scene>
<table><tr><td colspan='2'>[[1cs8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CS8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CS8 FirstGlance]. <br>
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Cathepsin_L Cathepsin L], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.15 3.4.22.15] </span>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
|GENE=
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=OCS:CYSTEINESULFONIC+ACID'>OCS</scene></td></tr>
|DOMAIN=
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1cs8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cs8 OCA], [https://pdbe.org/1cs8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1cs8 RCSB], [https://www.ebi.ac.uk/pdbsum/1cs8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1cs8 ProSAT]</span></td></tr>
|RELATEDENTRY=[[1cjl|1CJL]]
</table>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1cs8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cs8 OCA], [http://www.ebi.ac.uk/pdbsum/1cs8 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1cs8 RCSB]</span>
== Function ==
}}
[https://www.uniprot.org/uniprot/CATL1_HUMAN CATL1_HUMAN] Important for the overall degradation of proteins in lysosomes.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cs/1cs8_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1cs8 ConSurf].
<div style="clear:both"></div>


'''CRYSTAL STRUCTURE OF PROCATHEPSIN L'''
==See Also==
 
*[[Cathepsin 3D structures|Cathepsin 3D structures]]
 
__TOC__
==About this Structure==
</StructureSection>
1CS8 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CS8 OCA].
[[Category: Cathepsin L]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Coulombe, R.]]
[[Category: Coulombe R]]
[[Category: Cygler, M.]]
[[Category: Cygler M]]
[[Category: inhibition]]
[[Category: propeptide]]
[[Category: prosegment]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:27:32 2008''

Latest revision as of 18:42, 13 March 2024

CRYSTAL STRUCTURE OF PROCATHEPSIN LCRYSTAL STRUCTURE OF PROCATHEPSIN L

Structural highlights

1cs8 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.8Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

CATL1_HUMAN Important for the overall degradation of proteins in lysosomes.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

1cs8, resolution 1.80Å

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