1by6: Difference between revisions

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[[Image:1by6.png|left|200px]]


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==Peptide of human apolipoprotein C-II==
The line below this paragraph, containing "STRUCTURE_1by6", creates the "Structure Box" on the page.
<StructureSection load='1by6' size='340' side='right'caption='[[1by6]]' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1by6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BY6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BY6 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1by6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1by6 OCA], [https://pdbe.org/1by6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1by6 RCSB], [https://www.ebi.ac.uk/pdbsum/1by6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1by6 ProSAT]</span></td></tr>
{{STRUCTURE_1by6|  PDB=1by6  |  SCENE= }}
</table>
 
== Disease ==
===PEPTIDE OF HUMAN APOLIPOPROTEIN C-II===
[https://www.uniprot.org/uniprot/APOC2_HUMAN APOC2_HUMAN] Defects in APOC2 are the cause of hyperlipoproteinemia type 1B (HLPP1B) [MIM:[https://omim.org/entry/207750 207750]. It is an autosomal recessive trait characterized by hypertriglyceridemia, xanthomas, and increased risk of pancreatitis and early atherosclerosis.<ref>PMID:8323539</ref>
 
== Function ==
 
[https://www.uniprot.org/uniprot/APOC2_HUMAN APOC2_HUMAN] Component of the very low density lipoprotein (VLDL) fraction in plasma, and is an activator of several triacylglycerol lipases. The association of APOC2 with plasma chylomicrons, VLDL, and HDL is reversible, a function of the secretion and catabolism of triglyceride-rich lipoproteins, and changes rapidly.
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== Evolutionary Conservation ==
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Check<jmol>
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{{ABSTRACT_PUBMED_10903476}}
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/by/1by6_consurf.spt"</scriptWhenChecked>
 
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==About this Structure==
    <text>to colour the structure by Evolutionary Conservation</text>
1BY6 is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BY6 OCA].  
  </jmolCheckbox>
 
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1by6 ConSurf].
==Reference==
<div style="clear:both"></div>
<ref group="xtra">PMID:10903476</ref><references group="xtra"/>
== References ==
[[Category: Cushley, R J.]]
<references/>
[[Category: Rozek, A.]]
__TOC__
[[Category: Sparrow, J T.]]
</StructureSection>
[[Category: Storjohann, R.]]
[[Category: Homo sapiens]]
[[Category: Amphipathic helix]]
[[Category: Large Structures]]
[[Category: Apolipoprotein]]
[[Category: Cushley RJ]]
[[Category: Lipid association]]
[[Category: Rozek A]]
[[Category: Lpl activation]]
[[Category: Sparrow JT]]
 
[[Category: Storjohann R]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 12:34:54 2009''

Latest revision as of 18:37, 13 March 2024

Peptide of human apolipoprotein C-IIPeptide of human apolipoprotein C-II

Structural highlights

1by6 is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Solution NMR
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

APOC2_HUMAN Defects in APOC2 are the cause of hyperlipoproteinemia type 1B (HLPP1B) [MIM:207750. It is an autosomal recessive trait characterized by hypertriglyceridemia, xanthomas, and increased risk of pancreatitis and early atherosclerosis.[1]

Function

APOC2_HUMAN Component of the very low density lipoprotein (VLDL) fraction in plasma, and is an activator of several triacylglycerol lipases. The association of APOC2 with plasma chylomicrons, VLDL, and HDL is reversible, a function of the secretion and catabolism of triglyceride-rich lipoproteins, and changes rapidly.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

  1. ↑ Inadera H, Hibino A, Kobayashi J, Kanzaki T, Shirai K, Yukawa S, Saito Y, Yoshida S. A missense mutation (Trp 26-->Arg) in exon 3 of the apolipoprotein CII gene in a patient with apolipoprotein CII deficiency (apo CII-Wakayama). Biochem Biophys Res Commun. 1993 Jun 30;193(3):1174-83. PMID:8323539 doi:http://dx.doi.org/S0006-291X(83)71749-3
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