1ax8: Difference between revisions

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-{{Seed}}
-[[Image:1ax8.png|left|200px]]
-<!--
+==Human obesity protein, leptin==
-The line below this paragraph, containing "STRUCTURE_1ax8", creates the "Structure Box" on the page.
+<StructureSection load='1ax8' size='340' side='right'caption='[[1ax8]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1ax8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The May 2012 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Leptin''  by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2012_5 10.2210/rcsb_pdb/mom_2012_5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AX8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AX8 FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ax8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ax8 OCA], [https://pdbe.org/1ax8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ax8 RCSB], [https://www.ebi.ac.uk/pdbsum/1ax8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ax8 ProSAT]</span></td></tr>
-{{STRUCTURE_1ax8|  PDB=1ax8  |  SCENE=  }}
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/LEP_HUMAN LEP_HUMAN] Defects in LEP may be a cause of obesity (OBESITY) [MIM:[https://omim.org/entry/601665 601665]. It is a condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat.<ref>PMID:9500540</ref>
+== Function ==
+[https://www.uniprot.org/uniprot/LEP_HUMAN LEP_HUMAN] May function as part of a signaling pathway that acts to regulate the size of the body fat depot. An increase in the level of LEP may act directly or indirectly on the CNS to inhibit food intake and/or regulate energy expenditure as part of a homeostatic mechanism to maintain constancy of the adipose mass.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ax/1ax8_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ax8 ConSurf].
+<div style="clear:both"></div>
-===HUMAN OBESITY PROTEIN, LEPTIN===
+==See Also==
+*[[Flock house virus protein B2|Flock house virus protein B2]]
+*[[User:Mary Ball/Leptin|User:Mary Ball/Leptin]]
-<!--
+== References ==
-The line below this paragraph, {{ABSTRACT_PUBMED_9144295}}, adds the Publication Abstract to the page
+<references/>
-(as it appears on PubMed at http://www.pubmed.gov), where 9144295 is the PubMed ID number.
+__TOC__
--->
+</StructureSection>
-{{ABSTRACT_PUBMED_9144295}}
-==About this Structure==
-AX8 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AX8 OCA].
-==Reference==
-Crystal structure of the obese protein leptin-E100., Zhang F, Basinski MB, Beals JM, Briggs SL, Churgay LM, Clawson DK, DiMarchi RD, Furman TC, Hale JE, Hsiung HM, Schoner BE, Smith DP, Zhang XY, Wery JP, Schevitz RW, Nature. 1997 May 8;387(6629):206-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9144295 9144295]
 [[Category: Homo sapiens]]
-[[Category: Single protein]]
+[[Category: Large Structures]]
-[[Category: Beals, J M.]]
+[[Category: Leptin]]
-[[Category: Briggs, S L.]]
+[[Category: RCSB PDB Molecule of the Month]]
-[[Category: Clawson, D K.]]
+[[Category: Beals JM]]
-[[Category: Schevitz, R W.]]
+[[Category: Briggs SL]]
-[[Category: Wery, J P.]]
+[[Category: Clawson DK]]
-[[Category: Zhang, F.]]
+[[Category: Schevitz RW]]
-[[Category: Diabetes]]
+[[Category: Wery J-P]]
-[[Category: Helical cytokine]]
+[[Category: Zhang F]]
-[[Category: Hematopoietic factor]]
-[[Category: Obesity]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 17:47:07 2008''