1age: Difference between revisions

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-[[Image:1age.png|left|200px]]
-{{STRUCTURE_1age|  PDB=1age  |  SCENE=  }}
+==ANTAGONIST HIV-1 GAG PEPTIDES INDUCE STRUCTURAL CHANGES IN HLA B8-HIV-1 GAG PEPTIDE (GGKKKYRL-7R MUTATION)==
+<StructureSection load='1age' size='340' side='right'caption='[[1age]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
-===ANTAGONIST HIV-1 GAG PEPTIDES INDUCE STRUCTURAL CHANGES IN HLA B8-HIV-1 GAG PEPTIDE (GGKKKYRL-7R MUTATION)===
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1age]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AGE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AGE FirstGlance]. <br>
-{{ABSTRACT_PUBMED_8976183}}
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1age FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1age OCA], [https://pdbe.org/1age PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1age RCSB], [https://www.ebi.ac.uk/pdbsum/1age PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1age ProSAT]</span></td></tr>
-==About this Structure==
+</table>
-[[1age]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AGE OCA].
+== Disease ==
+[https://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[https://omim.org/entry/241600 241600]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref>   Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref>
+== Function ==
+[https://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ag/1age_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1age ConSurf].
+<div style="clear:both"></div>
 ==See Also==
-*[[Beta-2 microglobulin|Beta-2 microglobulin]]
+*[[Beta-2 microglobulin 3D structures|Beta-2 microglobulin 3D structures]]
-*[[Gag polyprotein|Gag polyprotein]]
+== References ==
+<references/>
-==Reference==
+__TOC__
-<ref group="xtra">PMID:008976183</ref><ref group="xtra">PMID:010422827</ref><references group="xtra"/>
+</StructureSection>
 [[Category: Homo sapiens]]
 [[Category: Human immunodeficiency virus 1]]
-[[Category: Bell, J.]]
+[[Category: Large Structures]]
-[[Category: Callaghan, C A.O.]]
+[[Category: Bell J]]
-[[Category: Harlos, K.]]
+[[Category: Harlos K]]
-[[Category: Jakobsen, B K.]]
+[[Category: Jakobsen BK]]
-[[Category: Jones, E Y.]]
+[[Category: Jones EY]]
-[[Category: Klenerman, P.]]
+[[Category: Klenerman P]]
-[[Category: Mcadam, S.]]
+[[Category: Mcadam S]]
-[[Category: Mcmichael, A J.]]
+[[Category: Mcmichael AJ]]
-[[Category: Reid, S W.]]
+[[Category: O'Callaghan CA]]
-[[Category: Smith, K J.]]
+[[Category: Reid SW]]
-[[Category: Stuart, D I.]]
+[[Category: Smith KJ]]
-[[Category: Histocompatibility complex]]
+[[Category: Stuart DI]]
-[[Category: Hiv]]
-[[Category: Hla b8]]
-[[Category: Mhc class i]]