1a3p: Difference between revisions

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-{{Seed}}
-[[Image:1a3p.png|left|200px]]
-<!--
+==ROLE OF THE 6-20 DISULFIDE BRIDGE IN THE STRUCTURE AND ACTIVITY OF EPIDERMAL GROWTH FACTOR, NMR, 20 STRUCTURES==
-The line below this paragraph, containing "STRUCTURE_1a3p", creates the "Structure Box" on the page.
+<StructureSection load='1a3p' size='340' side='right'caption='[[1a3p]]' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1a3p]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A3P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1A3P FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ABA:ALPHA-AMINOBUTYRIC+ACID'>ABA</scene></td></tr>
-{{STRUCTURE_1a3p|  PDB=1a3p  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1a3p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a3p OCA], [https://pdbe.org/1a3p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1a3p RCSB], [https://www.ebi.ac.uk/pdbsum/1a3p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1a3p ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/EGF_MOUSE EGF_MOUSE] EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity).
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a3/1a3p_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1a3p ConSurf].
+<div style="clear:both"></div>
-===ROLE OF THE 6-20 DISULFIDE BRIDGE IN THE STRUCTURE AND ACTIVITY OF EPIDERMAL GROWTH FACTOR, NMR, 20 STRUCTURES===
+==See Also==
+*[[Epidermal growth factor|Epidermal growth factor]]
+__TOC__
-<!--
+</StructureSection>
-The line below this paragraph, {{ABSTRACT_PUBMED_10082370}}, adds the Publication Abstract to the page
+[[Category: Large Structures]]
-(as it appears on PubMed at http://www.pubmed.gov), where 10082370 is the PubMed ID number.
--->
-{{ABSTRACT_PUBMED_10082370}}
-==About this Structure==
-A3P is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A3P OCA].
-==Reference==
-Role of the 6-20 disulfide bridge in the structure and activity of epidermal growth factor., Barnham KJ, Torres AM, Alewood D, Alewood PF, Domagala T, Nice EC, Norton RS, Protein Sci. 1998 Aug;7(8):1738-49. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10082370 10082370]
 [[Category: Mus musculus]]
-[[Category: Single protein]]
+[[Category: Alewood D]]
-[[Category: Alewood, D.]]
+[[Category: Alewood P]]
-[[Category: Alewood, P.]]
+[[Category: Barnham K]]
-[[Category: Barnham, K.]]
+[[Category: Domagala T]]
-[[Category: Domagala, T.]]
+[[Category: Nice E]]
-[[Category: Nice, E.]]
+[[Category: Norton R]]
-[[Category: Norton, R.]]
+[[Category: Torres A]]
-[[Category: Torres, A.]]
-[[Category: Disulfide connectivity]]
-[[Category: Egf-like domain]]
-[[Category: Growth factor]]
-[[Category: Murine epidermal growth factor]]
-[[Category: Repeat]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 15:56:40 2008''