6p8e: Difference between revisions

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-'''Unreleased structure'''
-The entry 6p8e is ON HOLD  until Paper Publication
+==Crystal structure of CDK4 in complex with CyclinD1 and P27==
+<StructureSection load='6p8e' size='340' side='right'caption='[[6p8e]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6p8e]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6P8E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6P8E FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6p8e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6p8e OCA], [https://pdbe.org/6p8e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6p8e RCSB], [https://www.ebi.ac.uk/pdbsum/6p8e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6p8e ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/CCND1_HUMAN CCND1_HUMAN] Note=A chromosomal aberration involving CCND1 may be a cause of B-lymphocytic malignancy, particularly mantle-cell lymphoma (MCL). Translocation t(11;14)(q13;q32) with immunoglobulin gene regions. Activation of CCND1 may be oncogenic by directly altering progression through the cell cycle.  Note=A chromosomal aberration involving CCND1 may be a cause of parathyroid adenomas. Translocation t(11;11)(q13;p15) with the parathyroid hormone (PTH) enhancer.  Defects in CCND1 are a cause of multiple myeloma (MM) [MIM:[https://omim.org/entry/254500 254500]. MM is a malignant tumor of plasma cells usually arising in the bone marrow and characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria and anemia. Complications of multiple myeloma are bone pain, hypercalcemia, renal failure and spinal cord compression. The aberrant antibodies that are produced lead to impaired humoral immunity and patients have a high prevalence of infection. Amyloidosis may develop in some patients. Multiple myeloma is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance (MGUS) to plasma cell leukemia. Note=A chromosomal aberration involving CCND1 is found in multiple myeloma. Translocation t(11;14)(q13;q32) with the IgH locus.
+== Function ==
+[https://www.uniprot.org/uniprot/CCND1_HUMAN CCND1_HUMAN] Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.<ref>PMID:9106657</ref> <ref>PMID:15241418</ref>
-Authors: Guiley, K.Z., Stevenson, J.W., Lou, K., Barkovich, K.J., Bunch, K., Tripathi, S.M., Shokat, K.M., Rubin, S.M.
+==See Also==
+*[[Cyclin-dependent kinase 3D structures|Cyclin-dependent kinase 3D structures]]
-Description: Crystal structure of CDK4 in complex with CyclinD1 and P27
+== References ==
-[[Category: Unreleased Structures]]
+<references/>
-[[Category: Guiley, K.Z]]
+__TOC__
-[[Category: Barkovich, K.J]]
+</StructureSection>
-[[Category: Stevenson, J.W]]
+[[Category: Homo sapiens]]
-[[Category: Shokat, K.M]]
+[[Category: Large Structures]]
-[[Category: Lou, K]]
+[[Category: Barkovich KJ]]
-[[Category: Rubin, S.M]]
+[[Category: Bunch K]]
-[[Category: Tripathi, S.M]]
+[[Category: Guiley KZ]]
-[[Category: Bunch, K]]
+[[Category: Lou K]]
+[[Category: Rubin SM]]
+[[Category: Shokat KM]]
+[[Category: Stevenson JW]]
+[[Category: Tripathi SM]]