|
|
| (One intermediate revision by the same user not shown) |
| Line 3: |
Line 3: |
| <SX load='6oeh' size='340' side='right' viewer='molstar' caption='[[6oeh]], [[Resolution|resolution]] 3.80Å' scene=''> | | <SX load='6oeh' size='340' side='right' viewer='molstar' caption='[[6oeh]], [[Resolution|resolution]] 3.80Å' scene=''> |
| == Structural highlights == | | == Structural highlights == |
| <table><tr><td colspan='2'>[[6oeh]] is a 14 chain structure with sequence from [http://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OEH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6OEH FirstGlance]. <br> | | <table><tr><td colspan='2'>[[6oeh]] is a 14 chain structure with sequence from [https://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OEH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6OEH FirstGlance]. <br> |
| </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr> | | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.8Å</td></tr> |
| <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6oeh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6oeh OCA], [http://pdbe.org/6oeh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6oeh RCSB], [http://www.ebi.ac.uk/pdbsum/6oeh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6oeh ProSAT]</span></td></tr> | | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6oeh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6oeh OCA], [https://pdbe.org/6oeh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6oeh RCSB], [https://www.ebi.ac.uk/pdbsum/6oeh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6oeh ProSAT]</span></td></tr> |
| </table> | | </table> |
| <div style="background-color:#fffaf0;">
| |
| == Publication Abstract from PubMed ==
| |
| Bacterial type IV secretion systems (T4SSs) are molecular machines that can mediate interbacterial DNA transfer through conjugation and delivery of effector molecules into host cells. The Helicobacter pylori Cag T4SS translocates CagA, a bacterial oncoprotein, into gastric cells, contributing to gastric cancer pathogenesis. We report the structure of a membrane-spanning Cag T4SS complex, which contains three sub-complexes: a 14-fold symmetric outer membrane core complex (OMCC), 17-fold symmetric periplasmic ring complex (PRC), and stalk domain. Features that differ markedly from those of prototypical T4SSs include an expanded OMCC and unexpected symmetry mismatch between the OMCC and PRC. This structure is one of the largest bacterial secretion system complexes ever reported and illustrates the remarkable structural diversity that exists among bacterial T4SSs.
| |
|
| |
| Structure of the Helicobacter pylori Cag Type IV secretion system.,Chung JM, Sheedlo MJ, Campbell AM, Sawhney N, Frick-Cheng AE, Lacy DB, Cover TL, Ohi MD Elife. 2019 Jun 18;8. pii: 47644. doi: 10.7554/eLife.47644. PMID:31210639<ref>PMID:31210639</ref>
| |
|
| |
| From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
| |
| </div>
| |
| <div class="pdbe-citations 6oeh" style="background-color:#fffaf0;"></div>
| |
| == References ==
| |
| <references/>
| |
| __TOC__ | | __TOC__ |
| </SX> | | </SX> |
| [[Category: Helicobacter pylori]] | | [[Category: Helicobacter pylori]] |
| [[Category: Large Structures]] | | [[Category: Large Structures]] |
| [[Category: Campbell, A]] | | [[Category: Campbell A]] |
| [[Category: Chung, J M]] | | [[Category: Chung JM]] |
| [[Category: Cover, T L]] | | [[Category: Cover TL]] |
| [[Category: Frick-Cheng, A E]] | | [[Category: Frick-Cheng AE]] |
| [[Category: Lacy, D B]] | | [[Category: Lacy DB]] |
| [[Category: Ohi, M D]] | | [[Category: Ohi MD]] |
| [[Category: Sawhney, N]] | | [[Category: Sawhney N]] |
| [[Category: Sheedlo, M J]] | | [[Category: Sheedlo MJ]] |
| [[Category: H. pylori]]
| |
| [[Category: Secretion]]
| |
| [[Category: T4ss]]
| |
| [[Category: Translocase]]
| |