6o7f: Difference between revisions

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-'''Unreleased structure'''
-The entry 6o7f is ON HOLD
+==Mycobacterium tuberculosis L-alanine dehydrogenase x-ray structure in complex with N6-isobutyl adenosine==
+<StructureSection load='6o7f' size='340' side='right'caption='[[6o7f]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
-Authors: Kim, H.-B., Hung, L.-W., Terwilliger, T.C., Kim, C.-Y., Structures of Mtb Proteins Conferring Susceptibility to Known Mtb Inhibitors (MTBI)
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6o7f]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6O7F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6O7F FirstGlance]. <br>
-Description: Mycobacterium tuberculosis L-alanine dehydrogenase x-ray structure in complex with N6-isobutyl adenosine
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.303&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NKV:N-(2-methylpropanoyl)adenosine'>NKV</scene></td></tr>
-[[Category: Terwilliger, T.C]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6o7f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6o7f OCA], [https://pdbe.org/6o7f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6o7f RCSB], [https://www.ebi.ac.uk/pdbsum/6o7f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6o7f ProSAT]</span></td></tr>
-[[Category: Structures Of Mtb Proteins Conferring Susceptibility To Known Mtb Inhibitors (Mtbi)]]
+</table>
-[[Category: Hung, L.-W]]
+== Function ==
-[[Category: Kim, H.-B]]
+[https://www.uniprot.org/uniprot/DHA_MYCTU DHA_MYCTU] Catalyzes the reversible reductive amination of pyruvate to L-alanine. However, since the physiological environment of M.tuberculosis has a neutral pH, it can be assumed that the enzyme catalyzes exclusively the formation of L-alanine. May play a role in cell wall synthesis as L-alanine is an important constituent of the peptidoglycan layer.<ref>PMID:10527947</ref>
-[[Category: Kim, C.-Y]]
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Mycobacterium tuberculosis H37Rv]]
+[[Category: Hung L-W]]
+[[Category: Kim C-Y]]
+[[Category: Kim H-B]]
+[[Category: Terwilliger TC]]