6nl4: Difference between revisions

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'''Unreleased structure'''


The entry 6nl4 is ON HOLD  until Paper Publication
==Crystal structure of Mycobacterium tuberculosis dethiobiotin synthetase in complex with gemcitabine==
<StructureSection load='6nl4' size='340' side='right'caption='[[6nl4]], [[Resolution|resolution]] 1.99&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6nl4]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NL4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6NL4 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.991&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GEO:GEMCITABINE'>GEO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6nl4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nl4 OCA], [https://pdbe.org/6nl4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6nl4 RCSB], [https://www.ebi.ac.uk/pdbsum/6nl4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6nl4 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/BIOD_MYCTU BIOD_MYCTU] Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring.<ref>PMID:20565114</ref>


Authors: Thompson, A.P., Polyak, S.W., Wegener, K.L., Bruning, J.B.
==See Also==
 
*[[Dethiobiotin synthetase 3D structures|Dethiobiotin synthetase 3D structures]]
Description: Crystal structure of Mycobacterium tuberculosis dethiobiotin synthetase in complex with gemcitabine
== References ==
[[Category: Unreleased Structures]]
<references/>
[[Category: Polyak, S.W]]
__TOC__
[[Category: Bruning, J.B]]
</StructureSection>
[[Category: Thompson, A.P]]
[[Category: Large Structures]]
[[Category: Wegener, K.L]]
[[Category: Mycobacterium tuberculosis H37Rv]]
[[Category: Bruning JB]]
[[Category: Polyak SW]]
[[Category: Thompson AP]]
[[Category: Wegener KL]]

Latest revision as of 17:48, 13 March 2024

Crystal structure of Mycobacterium tuberculosis dethiobiotin synthetase in complex with gemcitabineCrystal structure of Mycobacterium tuberculosis dethiobiotin synthetase in complex with gemcitabine

Structural highlights

6nl4 is a 4 chain structure with sequence from Mycobacterium tuberculosis H37Rv. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.991Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

BIOD_MYCTU Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring.[1]

See Also

References

  1. ↑ Dey S, Lane JM, Lee RE, Rubin EJ, Sacchettini JC. Structural characterization of the Mycobacterium tuberculosis biotin biosynthesis enzymes 7,8-diaminopelargonic acid synthase and dethiobiotin synthetase . Biochemistry. 2010 Aug 10;49(31):6746-60. PMID:20565114 doi:10.1021/bi902097j

6nl4, resolution 1.99Å

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