6myn: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-'''Unreleased structure'''
-The entry 6myn is ON HOLD
+==Crystal structure of murine NF-kappaB inducing kinase (NIK) bound to inhibitor R7==
+<StructureSection load='6myn' size='340' side='right'caption='[[6myn]], [[Resolution|resolution]] 2.74&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6myn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MYN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6MYN FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.744&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K6Y:(5s,7s)-9-fluoro-10-[(3R)-3-hydroxy-3-(5-methyl-1,2-oxazol-3-yl)but-1-yn-1-yl]-N~3~-methyl-6,7-dihydro-5H-5,7-methanoimidazo[2,1-a][2]benzazepine-2,3-dicarboxamide'>K6Y</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6myn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6myn OCA], [https://pdbe.org/6myn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6myn RCSB], [https://www.ebi.ac.uk/pdbsum/6myn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6myn ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/M3K14_MOUSE M3K14_MOUSE] Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity. Promotes proteolytic processing of NFKB2/P100, which leads to activation of NF-kappa-B via the non-canonical pathway. Could act in a receptor-selective manner.<ref>PMID:11239468</ref>
-Authors: Harris, S.F., Smith, M., Barker, J.
+==See Also==
+*[[Mitogen-activated protein kinase kinase kinase|Mitogen-activated protein kinase kinase kinase]]
-Description: Crystal structure of murine NF-kappaB inducing kinase (NIK) bound to inhibitor R7
+== References ==
-[[Category: Unreleased Structures]]
+<references/>
-[[Category: Harris, S.F]]
+__TOC__
-[[Category: Barker, J]]
+</StructureSection>
-[[Category: Smith, M]]
+[[Category: Large Structures]]
+[[Category: Mus musculus]]
+[[Category: Barker J]]
+[[Category: Harris SF]]
+[[Category: Smith M]]