6ms7: Difference between revisions

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OCA

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-'''Unreleased structure'''
-The entry 6ms7 is ON HOLD
+==Peroxisome proliferator-activated receptor gamma ligand binding domain in complex with a novel selective PPAR-gamma modulator VSP-77==
+<StructureSection load='6ms7' size='340' side='right'caption='[[6ms7]], [[Resolution|resolution]] 1.43&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6ms7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MS7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6MS7 FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.43&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=V77:{[(1S)-1-(4-chlorophenyl)octyl]oxy}acetic+acid'>V77</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ms7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ms7 OCA], [https://pdbe.org/6ms7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ms7 RCSB], [https://www.ebi.ac.uk/pdbsum/6ms7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ms7 ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/PPARG_HUMAN PPARG_HUMAN] Note=Defects in PPARG can lead to type 2 insulin-resistant diabetes and hyptertension. PPARG mutations may be associated with colon cancer.  Defects in PPARG may be associated with susceptibility to obesity (OBESITY) [MIM:[https://omim.org/entry/601665 601665]. It is a condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat.<ref>PMID:9753710</ref>   Defects in PPARG are the cause of familial partial lipodystrophy type 3 (FPLD3) [MIM:[https://omim.org/entry/604367 604367]. Familial partial lipodystrophies (FPLD) are a heterogeneous group of genetic disorders characterized by marked loss of subcutaneous (sc) fat from the extremities. Affected individuals show an increased preponderance of insulin resistance, diabetes mellitus and dyslipidemia.<ref>PMID:12453919</ref> <ref>PMID:11788685</ref>   Genetic variations in PPARG can be associated with susceptibility to glioma type 1 (GLM1) [MIM:[https://omim.org/entry/137800 137800]. Gliomas are central nervous system neoplasms derived from glial cells and comprise astrocytomas, glioblastoma multiforme, oligodendrogliomas, and ependymomas. Note=Polymorphic PPARG alleles have been found to be significantly over-represented among a cohort of American patients with sporadic glioblastoma multiforme suggesting a possible contribution to disease susceptibility.
+== Function ==
+[https://www.uniprot.org/uniprot/PPARG_HUMAN PPARG_HUMAN] Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated proinflammatory responses.<ref>PMID:9065481</ref> <ref>PMID:16150867</ref> <ref>PMID:20829347</ref>
-Authors: Yi, W., Jiang, H., Zhou, X.E., Shi, J., Zhao, G., Zhang, X., Sun, Y., Suino-Powell, K., Li, J., Li, J., Melcher, K., Xu, H.E.
+==See Also==
+*[[Peroxisome proliferator-activated receptor 3D structures|Peroxisome proliferator-activated receptor 3D structures]]
-Description: Peroxisome proliferator-activated receptor gamma ligand binding domain in complex with a novel selective PPAR-gamma modulator VSP-77
+== References ==
-[[Category: Unreleased Structures]]
+<references/>
-[[Category: Zhou, X.E]]
+__TOC__
-[[Category: Xu, H.E]]
+</StructureSection>
-[[Category: Melcher, K]]
+[[Category: Homo sapiens]]
-[[Category: Jiang, H]]
+[[Category: Large Structures]]
-[[Category: Shi, J]]
+[[Category: Synthetic construct]]
-[[Category: Li, J]]
+[[Category: Jiang H]]
-[[Category: Zhao, G]]
+[[Category: Li J]]
-[[Category: Suino-Powell, K]]
+[[Category: Melcher K]]
-[[Category: Yi, W]]
+[[Category: Shi J]]
-[[Category: Sun, Y]]
+[[Category: Suino-Powell K]]
-[[Category: Zhang, X]]
+[[Category: Sun Y]]
+[[Category: Xu HE]]
+[[Category: Yi W]]
+[[Category: Zhang X]]
+[[Category: Zhao G]]
+[[Category: Zhou XE]]