6m7z: Difference between revisions

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'''Unreleased structure'''


The entry 6m7z is ON HOLD  until Oct 16 2019
==A divergent kinase lacking the glycine-rich loop regulates membrane ultrastructure of the Toxoplasma parasitophorous vacuole==
 
<StructureSection load='6m7z' size='340' side='right'caption='[[6m7z]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
Authors: Beraki, T., Borek, D.M., Reese, M.L.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[6m7z]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Toxoplasma_gondii_RH Toxoplasma gondii RH]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6M7Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6M7Z FirstGlance]. <br>
Description: A divergent kinase lacking the glycine-rich loop regulates membrane ultrastructure of the Toxoplasma parasitophorous vacuole (CASP target)
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
[[Category: Borek, D.M]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6m7z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6m7z OCA], [https://pdbe.org/6m7z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6m7z RCSB], [https://www.ebi.ac.uk/pdbsum/6m7z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6m7z ProSAT]</span></td></tr>
[[Category: Beraki, T]]
</table>
[[Category: Reese, M.L]]
== Function ==
[https://www.uniprot.org/uniprot/BPK1_TOXGO BPK1_TOXGO] Required for the growth, maintenance, and/or stability, and thus infectivity, of bradyzoite cysts.<ref>PMID:23291621</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Toxoplasma gondii RH]]
[[Category: Beraki T]]
[[Category: Borek DM]]
[[Category: Reese ML]]

Latest revision as of 17:41, 13 March 2024

A divergent kinase lacking the glycine-rich loop regulates membrane ultrastructure of the Toxoplasma parasitophorous vacuoleA divergent kinase lacking the glycine-rich loop regulates membrane ultrastructure of the Toxoplasma parasitophorous vacuole

Structural highlights

6m7z is a 6 chain structure with sequence from Toxoplasma gondii RH. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.5Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

BPK1_TOXGO Required for the growth, maintenance, and/or stability, and thus infectivity, of bradyzoite cysts.[1]

References

  1. ↑ Buchholz KR, Bowyer PW, Boothroyd JC. Bradyzoite pseudokinase 1 is crucial for efficient oral infectivity of the Toxoplasma gondii tissue cyst. Eukaryot Cell. 2013 Mar;12(3):399-410. PMID:23291621 doi:10.1128/EC.00343-12

6m7z, resolution 2.50Å

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