6ef1: Difference between revisions
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The | ==Yeast 26S proteasome bound to ubiquitinated substrate (5D motor state)== | ||
<SX load='6ef1' size='340' side='right' viewer='molstar' caption='[[6ef1]], [[Resolution|resolution]] 4.73Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6ef1]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EF1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6EF1 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.73Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ef1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ef1 OCA], [https://pdbe.org/6ef1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ef1 RCSB], [https://www.ebi.ac.uk/pdbsum/6ef1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ef1 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/PSA1_YEAST PSA1_YEAST] The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity. | |||
==See Also== | |||
*[[Proteasome 3D structures|Proteasome 3D structures]] | |||
__TOC__ | |||
[[Category: | </SX> | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Gates | [[Category: Saccharomyces cerevisiae S288C]] | ||
[[Category: Lander | [[Category: Gates SN]] | ||
[[Category: | [[Category: Goodall EA]] | ||
[[Category: | [[Category: Lander GC]] | ||
[[Category: Martin A]] | |||
[[Category: De la Pena AH]] | |||
Latest revision as of 17:41, 13 March 2024
Yeast 26S proteasome bound to ubiquitinated substrate (5D motor state)Yeast 26S proteasome bound to ubiquitinated substrate (5D motor state)
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