6ee4: Difference between revisions

Latest revision as of 17:40, 13 March 2024

X-ray crystal structure of Pf-M1 in complex with inhibitor (6m) and catalytic zinc ionX-ray crystal structure of Pf-M1 in complex with inhibitor (6m) and catalytic zinc ion

Structural highlights

6ee4 is a 1 chain structure with sequence from Plasmodium falciparum FcB1/Columbia. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 1.58Å
Ligands:	, , , ,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

AMP1_PLAFQ Displays aminopeptidase activity with a broad substrate specificity. Preferentially hydrolyzes L-Lys-AMC but also shows strong activity against L-Ala-AMC, L-Arg-AMC and L-Leu-AMC.^[1] ^[2]

References

↑ Allary M, Schrevel J, Florent I. Properties, stage-dependent expression and localization of Plasmodium falciparum M1 family zinc-aminopeptidase. Parasitology. 2002 Jul;125(Pt 1):1-10. PMID:12166515
↑ McGowan S, Porter CJ, Lowther J, Stack CM, Golding SJ, Skinner-Adams TS, Trenholme KR, Teuscher F, Donnelly SM, Grembecka J, Mucha A, Kafarski P, Degori R, Buckle AM, Gardiner DL, Whisstock JC, Dalton JP. Structural basis for the inhibition of the essential Plasmodium falciparum M1 neutral aminopeptidase. Proc Natl Acad Sci U S A. 2009 Feb 5. PMID:19196988

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OCA

[1] Allary M, Schrevel J, Florent I. Properties, stage-dependent expression and localization of Plasmodium falciparum M1 family zinc-aminopeptidase. Parasitology. 2002 Jul;125(Pt 1):1-10. PMID:12166515

[2] McGowan S, Porter CJ, Lowther J, Stack CM, Golding SJ, Skinner-Adams TS, Trenholme KR, Teuscher F, Donnelly SM, Grembecka J, Mucha A, Kafarski P, Degori R, Buckle AM, Gardiner DL, Whisstock JC, Dalton JP. Structural basis for the inhibition of the essential Plasmodium falciparum M1 neutral aminopeptidase. Proc Natl Acad Sci U S A. 2009 Feb 5. PMID:19196988

[1]

[2]

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6ee4 is ON HOLD  until Aug 13 2020
+==X-ray crystal structure of Pf-M1 in complex with inhibitor (6m) and catalytic zinc ion==
+<StructureSection load='6ee4' size='340' side='right'caption='[[6ee4]], [[Resolution|resolution]] 1.58&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6ee4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum_FcB1/Columbia Plasmodium falciparum FcB1/Columbia]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EE4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6EE4 FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.58&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=J4S:(2R)-2-[(cyclopropylacetyl)amino]-N-hydroxy-2-(3,4,5-trifluoro[1,1-biphenyl]-4-yl)acetamide'>J4S</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ee4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ee4 OCA], [https://pdbe.org/6ee4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ee4 RCSB], [https://www.ebi.ac.uk/pdbsum/6ee4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ee4 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/AMP1_PLAFQ AMP1_PLAFQ] Displays aminopeptidase activity with a broad substrate specificity. Preferentially hydrolyzes L-Lys-AMC but also shows strong activity against L-Ala-AMC, L-Arg-AMC and L-Leu-AMC.<ref>PMID:12166515</ref> <ref>PMID:19196988</ref>
-Authors: Drinkwater, N., McGowan, S.
+==See Also==
+*[[Aminopeptidase 3D structures|Aminopeptidase 3D structures]]
-Description: X-ray crystal structure of Pf-M1 in complex with inhibitor (6m) and catalytic zinc ion
+== References ==
-[[Category: Unreleased Structures]]
+<references/>
-[[Category: Drinkwater, N]]
+__TOC__
-[[Category: Mcgowan, S]]
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Plasmodium falciparum FcB1/Columbia]]
+[[Category: Drinkwater N]]
+[[Category: McGowan S]]

6ee4: Difference between revisions

Latest revision as of 17:40, 13 March 2024

X-ray crystal structure of Pf-M1 in complex with inhibitor (6m) and catalytic zinc ionX-ray crystal structure of Pf-M1 in complex with inhibitor (6m) and catalytic zinc ion

Structural highlights

Function

See Also

References

Contents

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6ee4: Difference between revisions

Latest revision as of 17:40, 13 March 2024

X-ray crystal structure of Pf-M1 in complex with inhibitor (6m) and catalytic zinc ionX-ray crystal structure of Pf-M1 in complex with inhibitor (6m) and catalytic zinc ion

Structural highlights

Function

See Also

References

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