6ea1: Difference between revisions
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New page: '''Unreleased structure''' The entry 6ea1 is ON HOLD Authors: Drinkwater, N., McGowan, S. Description: X-ray crystal structure of Pf-M1 in complex with inhibitor (6da) and catalytic zi... |
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==X-ray crystal structure of Pf-M1 in complex with inhibitor (6da) and catalytic zinc ion== | |||
<StructureSection load='6ea1' size='340' side='right'caption='[[6ea1]], [[Resolution|resolution]] 1.81Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6ea1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum_FcB1/Columbia Plasmodium falciparum FcB1/Columbia]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EA1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6EA1 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.815Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=J0Y:(2R)-2,3,3,3-tetrafluoro-N-[(1R)-2-(hydroxyamino)-2-oxo-1-(3,4,5-trifluoro[1,1-biphenyl]-4-yl)ethyl]propanamide'>J0Y</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ea1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ea1 OCA], [https://pdbe.org/6ea1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ea1 RCSB], [https://www.ebi.ac.uk/pdbsum/6ea1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ea1 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/AMP1_PLAFQ AMP1_PLAFQ] Displays aminopeptidase activity with a broad substrate specificity. Preferentially hydrolyzes L-Lys-AMC but also shows strong activity against L-Ala-AMC, L-Arg-AMC and L-Leu-AMC.<ref>PMID:12166515</ref> <ref>PMID:19196988</ref> | |||
==See Also== | |||
*[[Aminopeptidase 3D structures|Aminopeptidase 3D structures]] | |||
== References == | |||
[[Category: | <references/> | ||
[[Category: Drinkwater | __TOC__ | ||
[[Category: | </StructureSection> | ||
[[Category: Large Structures]] | |||
[[Category: Plasmodium falciparum FcB1/Columbia]] | |||
[[Category: Drinkwater N]] | |||
[[Category: McGowan S]] | |||
Latest revision as of 17:40, 13 March 2024
X-ray crystal structure of Pf-M1 in complex with inhibitor (6da) and catalytic zinc ionX-ray crystal structure of Pf-M1 in complex with inhibitor (6da) and catalytic zinc ion
Structural highlights
FunctionAMP1_PLAFQ Displays aminopeptidase activity with a broad substrate specificity. Preferentially hydrolyzes L-Lys-AMC but also shows strong activity against L-Ala-AMC, L-Arg-AMC and L-Leu-AMC.[1] [2] See AlsoReferences
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