6e9d: Difference between revisions

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-'''Unreleased structure'''
-The entry 6e9d is ON HOLD
+==Sub-2 Angstrom Ewald Curvature-Corrected Single-Particle Cryo-EM Reconstruction of AAV-2 L336C==
+<SX load='6e9d' size='340' side='right' viewer='molstar' caption='[[6e9d]], [[Resolution|resolution]] 1.86&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6e9d]] is a 60 chain structure with sequence from [https://en.wikipedia.org/wiki/Adeno-associated_virus_2_Srivastava/1982 Adeno-associated virus 2 Srivastava/1982]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6E9D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6E9D FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 1.86&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6e9d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6e9d OCA], [https://pdbe.org/6e9d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6e9d RCSB], [https://www.ebi.ac.uk/pdbsum/6e9d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6e9d ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/CAPSD_AAV2S CAPSD_AAV2S] Capsid protein self-assembles to form an icosahedral capsid with a T=1 symmetry, about 22 nm in diameter, and consisting of 60 copies of three size variants of the capsid protein VP1, VP2 and VP3 which differ in their N-terminus. The capsid encapsulates the genomic ssDNA. Binds to host cell heparan sulfate and uses host ITGA5-ITGB1 as coreceptor on the cell surface to provide virion attachment to target cell. This attachment induces virion internalization predominantly through clathrin-dependent endocytosis. Binding to the host receptor also induces capsid rearrangements leading to surface exposure of VP1 N-terminus, specifically its phospholipase A2-like region and putative nuclear localization signal(s). VP1 N-terminus might serve as a lipolytic enzyme to breach the endosomal membrane during entry into host cell and might contribute to virus transport to the nucleus.<ref>PMID:10684294</ref> <ref>PMID:11961250</ref> <ref>PMID:16940508</ref> <ref>PMID:9445046</ref>
-Authors: Tan, Y.Z., Aiyer, S., Mietzsch, M., Hull, J.A., McKenna, R., Baker, T.S., Agbandje-McKenna, M., Lyumkis, D.
+==See Also==
+*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
-Description: Sub-2 Angstrom Ewald Curvature-Corrected Single-Particle Cryo-EM Reconstruction of AAV-2 L336C
+== References ==
-[[Category: Unreleased Structures]]
+<references/>
-[[Category: Baker, T.S]]
+__TOC__
-[[Category: Tan, Y.Z]]
+</SX>
-[[Category: Hull, J.A]]
+[[Category: Adeno-associated virus 2 Srivastava/1982]]
-[[Category: Aiyer, S]]
+[[Category: Large Structures]]
-[[Category: Mckenna, R]]
+[[Category: Agbandje-McKenna M]]
-[[Category: Lyumkis, D]]
+[[Category: Aiyer S]]
-[[Category: Mietzsch, M]]
+[[Category: Baker TS]]
-[[Category: Agbandje-Mckenna, M]]
+[[Category: Hull JA]]
+[[Category: Lyumkis D]]
+[[Category: McKenna R]]
+[[Category: Mietzsch M]]
+[[Category: Tan YZ]]