6dmu: Difference between revisions
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The | ==PI(4,5)P2 bound full-length rbTRPV5== | ||
<SX load='6dmu' size='340' side='right' viewer='molstar' caption='[[6dmu]], [[Resolution|resolution]] 4.00Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6dmu]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DMU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6DMU FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PIO:[(2R)-2-OCTANOYLOXY-3-[OXIDANYL-[(1R,2R,3S,4R,5R,6S)-2,3,6-TRIS(OXIDANYL)-4,5-DIPHOSPHONOOXY-CYCLOHEXYL]OXY-PHOSPHORYL]OXY-PROPYL]+OCTANOATE'>PIO</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6dmu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dmu OCA], [https://pdbe.org/6dmu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6dmu RCSB], [https://www.ebi.ac.uk/pdbsum/6dmu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6dmu ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/TRPV5_RABIT TRPV5_RABIT] Constitutively active calcium selective cation channel thought to be involved in Ca(2+) reabsorption in kidney and intestine (PubMed:12574114). Required for normal Ca(2+) reabsorption in the kidney distal convoluted tubules (By similarity). The channel is activated by low internal calcium level and the current exhibits an inward rectification (By similarity). A Ca(2+)-dependent feedback regulation includes fast channel inactivation and slow current decay (By similarity). Heteromeric assembly with TRPV6 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating (PubMed:12574114).[UniProtKB:P69744][UniProtKB:Q9NQA5]<ref>PMID:10085067</ref> <ref>PMID:11035011</ref> <ref>PMID:12574114</ref> | |||
==See Also== | |||
*[[Ion channels 3D structures|Ion channels 3D structures]] | |||
== References == | |||
[[Category: | <references/> | ||
[[Category: Hughes | __TOC__ | ||
[[Category: Moiseenkova-Bell | </SX> | ||
[[Category: Pumroy | [[Category: Large Structures]] | ||
[[Category: Oryctolagus cuniculus]] | |||
[[Category: Hughes TET]] | |||
[[Category: Moiseenkova-Bell VY]] | |||
[[Category: Pumroy RA]] | |||
Latest revision as of 17:35, 13 March 2024
PI(4,5)P2 bound full-length rbTRPV5PI(4,5)P2 bound full-length rbTRPV5
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