6dmu: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-'''Unreleased structure'''
-The entry 6dmu is ON HOLD
+==PI(4,5)P2 bound full-length rbTRPV5==
+<SX load='6dmu' size='340' side='right' viewer='molstar' caption='[[6dmu]], [[Resolution|resolution]] 4.00&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6dmu]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DMU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6DMU FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PIO:[(2R)-2-OCTANOYLOXY-3-[OXIDANYL-[(1R,2R,3S,4R,5R,6S)-2,3,6-TRIS(OXIDANYL)-4,5-DIPHOSPHONOOXY-CYCLOHEXYL]OXY-PHOSPHORYL]OXY-PROPYL]+OCTANOATE'>PIO</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6dmu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dmu OCA], [https://pdbe.org/6dmu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6dmu RCSB], [https://www.ebi.ac.uk/pdbsum/6dmu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6dmu ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/TRPV5_RABIT TRPV5_RABIT] Constitutively active calcium selective cation channel thought to be involved in Ca(2+) reabsorption in kidney and intestine (PubMed:12574114). Required for normal Ca(2+) reabsorption in the kidney distal convoluted tubules (By similarity). The channel is activated by low internal calcium level and the current exhibits an inward rectification (By similarity). A Ca(2+)-dependent feedback regulation includes fast channel inactivation and slow current decay (By similarity). Heteromeric assembly with TRPV6 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating (PubMed:12574114).[UniProtKB:P69744][UniProtKB:Q9NQA5]<ref>PMID:10085067</ref> <ref>PMID:11035011</ref> <ref>PMID:12574114</ref>
-Authors: Hughes, T.E.T., Pumroy, R.A., Moiseenkova-Bell, V.Y.
+==See Also==
+*[[Ion channels 3D structures|Ion channels 3D structures]]
-Description: Calmodulin-bound full-length rbTRPV5 with C4 imposed symmetry
+== References ==
-[[Category: Unreleased Structures]]
+<references/>
-[[Category: Hughes, T.E.T]]
+__TOC__
-[[Category: Pumroy, R.A]]
+</SX>
-[[Category: Moiseenkova-Bell, V.Y]]
+[[Category: Large Structures]]
+[[Category: Oryctolagus cuniculus]]
+[[Category: Hughes TET]]
+[[Category: Moiseenkova-Bell VY]]
+[[Category: Pumroy RA]]