6d3m: Difference between revisions

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'''Unreleased structure'''


The entry 6d3m is ON HOLD  until Paper Publication
==FT_T dioxygenase with bound quizalofop==
<StructureSection load='6d3m' size='340' side='right'caption='[[6d3m]], [[Resolution|resolution]] 2.03&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6d3m]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Sphingobium_herbicidovorans Sphingobium herbicidovorans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6D3M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6D3M FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.03&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AKG:2-OXOGLUTARIC+ACID'>AKG</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=FTJ:(2R)-2-{4-[(6-chloroquinoxalin-2-yl)oxy]phenoxy}propanoic+acid'>FTJ</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6d3m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6d3m OCA], [https://pdbe.org/6d3m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6d3m RCSB], [https://www.ebi.ac.uk/pdbsum/6d3m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6d3m ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/RDPA_SPHHM RDPA_SPHHM] Involved in the degradation of the phenoxypropionate herbicides. Catalyzes the enantiospecific cleavage of the ether bond in the herbicid R-dichlorprop ((R)-2-(2,4-dichlorophenoxy)propionate)(R-2,4-DP) and R-mecoprop ((R)-2-(4-chloro-2-methylphenoxy)propionate)(R-2,4-MCPP). It can also accept (RS)-4-chlorophenoxypropanoate, however it can only accept 2-oxoglutarate as oxygen acceptor.<ref>PMID:16731970</ref> <ref>PMID:16820480</ref> <ref>PMID:11423952</ref>


Authors: Rydel, T.J., Halls, C.E.
==See Also==
 
*[[Dioxygenase 3D structures|Dioxygenase 3D structures]]
Description: FT_T dioxygenase with bound quizalofop
== References ==
[[Category: Unreleased Structures]]
<references/>
[[Category: Halls, C.E]]
__TOC__
[[Category: Rydel, T.J]]
</StructureSection>
[[Category: Large Structures]]
[[Category: Sphingobium herbicidovorans]]
[[Category: Halls CE]]
[[Category: Rydel TJ]]

Latest revision as of 17:32, 13 March 2024

FT_T dioxygenase with bound quizalofopFT_T dioxygenase with bound quizalofop

Structural highlights

6d3m is a 4 chain structure with sequence from Sphingobium herbicidovorans. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.03Å
Ligands:, , ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

RDPA_SPHHM Involved in the degradation of the phenoxypropionate herbicides. Catalyzes the enantiospecific cleavage of the ether bond in the herbicid R-dichlorprop ((R)-2-(2,4-dichlorophenoxy)propionate)(R-2,4-DP) and R-mecoprop ((R)-2-(4-chloro-2-methylphenoxy)propionate)(R-2,4-MCPP). It can also accept (RS)-4-chlorophenoxypropanoate, however it can only accept 2-oxoglutarate as oxygen acceptor.[1] [2] [3]

See Also

References

  1. ↑ Muller TA, Zavodszky MI, Feig M, Kuhn LA, Hausinger RP. Structural basis for the enantiospecificities of R- and S-specific phenoxypropionate/alpha-ketoglutarate dioxygenases. Protein Sci. 2006 Jun;15(6):1356-68. doi: 10.1110/ps.052059406. PMID:16731970 doi:http://dx.doi.org/10.1110/ps.052059406
  2. ↑ Muller TA, Fleischmann T, van der Meer JR, Kohler HP. Purification and characterization of two enantioselective alpha-ketoglutarate-dependent dioxygenases, RdpA and SdpA, from Sphingomonas herbicidovorans MH. Appl Environ Microbiol. 2006 Jul;72(7):4853-61. doi: 10.1128/AEM.02758-05. PMID:16820480 doi:http://dx.doi.org/10.1128/AEM.02758-05
  3. ↑ Kohler HP. Sphingomonas herbicidovorans MH: a versatile phenoxyalkanoic acid herbicide degrader. J Ind Microbiol Biotechnol. 1999 Oct;23(4-5):336-340. doi:, 10.1038/sj/jim/2900751. PMID:11423952 doi:http://dx.doi.org/10.1038/sj/jim/2900751

6d3m, resolution 2.03Å

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