6d1s: Difference between revisions
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==Crystal structure of an apo chimeric human alpha1GABAA receptor== | |||
<StructureSection load='6d1s' size='340' side='right'caption='[[6d1s]], [[Resolution|resolution]] 3.20Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6d1s]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Dickeya_dadantii_3937 Dickeya dadantii 3937] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6D1S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6D1S FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2Å</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6d1s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6d1s OCA], [https://pdbe.org/6d1s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6d1s RCSB], [https://www.ebi.ac.uk/pdbsum/6d1s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6d1s ProSAT]</span></td></tr> | |||
</table> | |||
== Disease == | |||
[https://www.uniprot.org/uniprot/GBRA1_HUMAN GBRA1_HUMAN] Juvenile myoclonic epilepsy;Childhood absence epilepsy;Dravet syndrome. Disease susceptibility is associated with variations affecting the gene represented in this entry. Disease susceptibility is associated with variations affecting the gene represented in this entry. Disease susceptibility is associated with variations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. | |||
== Function == | |||
[https://www.uniprot.org/uniprot/E0SJQ4_DICD3 E0SJQ4_DICD3] [https://www.uniprot.org/uniprot/GBRA1_HUMAN GBRA1_HUMAN] Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel (By similarity). | |||
==See Also== | |||
*[[GABA receptor 3D structures|GABA receptor 3D structures]] | |||
__TOC__ | |||
[[Category: | </StructureSection> | ||
[[Category: | [[Category: Dickeya dadantii 3937]] | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Arjunan | [[Category: Large Structures]] | ||
[[Category: Chen | [[Category: Arjunan P]] | ||
[[Category: Xu | [[Category: Chen Q]] | ||
[[Category: Cohen AE]] | |||
[[Category: Tang P]] | |||
[[Category: Xu Y]] | |||
Latest revision as of 17:32, 13 March 2024
Crystal structure of an apo chimeric human alpha1GABAA receptorCrystal structure of an apo chimeric human alpha1GABAA receptor
Structural highlights
DiseaseGBRA1_HUMAN Juvenile myoclonic epilepsy;Childhood absence epilepsy;Dravet syndrome. Disease susceptibility is associated with variations affecting the gene represented in this entry. Disease susceptibility is associated with variations affecting the gene represented in this entry. Disease susceptibility is associated with variations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. FunctionE0SJQ4_DICD3 GBRA1_HUMAN Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel (By similarity). See Also |
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