6cro: Difference between revisions

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-{{Seed}}
-[[Image:6cro.png|left|200px]]
-<!--
+==CRYSTAL STRUCTURE OF LAMBDA-CRO BOUND TO A CONSENSUS OPERATOR AT 3.0 ANGSTROM RESOLUTION==
-The line below this paragraph, containing "STRUCTURE_6cro", creates the "Structure Box" on the page.
+<StructureSection load='6cro' size='340' side='right'caption='[[6cro]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[6cro]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_virus_Lambda Escherichia virus Lambda]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CRO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6CRO FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-{{STRUCTURE_6cro|  PDB=6cro  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6cro FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cro OCA], [https://pdbe.org/6cro PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6cro RCSB], [https://www.ebi.ac.uk/pdbsum/6cro PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6cro ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/RCRO_LAMBD RCRO_LAMBD] Cro represses genes normally expressed in early phage development and is necessary for the late stage of lytic growth. It does this by binding to the OL and OR operators regions normally used by the repressor protein for lysogenic maintenance.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cr/6cro_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=6cro ConSurf].
+<div style="clear:both"></div>
-===CRYSTAL STRUCTURE OF LAMBDA-CRO BOUND TO A CONSENSUS OPERATOR AT 3.0 ANGSTROM RESOLUTION===
+==See Also==
+*[[Tomato aspermy virus protein 2b Suppression of RNA Silencing|Tomato aspermy virus protein 2b Suppression of RNA Silencing]]
+__TOC__
-<!--
+</StructureSection>
-The line below this paragraph, {{ABSTRACT_PUBMED_9653037}}, adds the Publication Abstract to the page
+[[Category: Escherichia virus Lambda]]
-(as it appears on PubMed at http://www.pubmed.gov), where 9653037 is the PubMed ID number.
+[[Category: Large Structures]]
--->
+[[Category: Albright RA]]
-{{ABSTRACT_PUBMED_9653037}}
+[[Category: Matthews BW]]
-==About this Structure==
-CRO is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_lambda Enterobacteria phage lambda]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CRO OCA].
-==Reference==
-Crystal structure of lambda-Cro bound to a consensus operator at 3.0 A resolution., Albright RA, Matthews BW, J Mol Biol. 1998 Jul 3;280(1):137-51. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9653037 9653037]
-[[Category: Enterobacteria phage lambda]]
-[[Category: Single protein]]
-[[Category: Albright, R A.]]
-[[Category: Matthews, B W.]]
-[[Category: Bacteriophage lambda]]
-[[Category: Conformational change]]
-[[Category: Cro]]
-[[Category: Helix-turn-helix]]
-[[Category: Repressor]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul  3 14:16:58 2008''