6bfn: Difference between revisions

<StructureSection load='6bfn' size='340' side='right'caption='[[6bfn]], [[Resolution|resolution]] 2.26&Aring;' scene=''>

<table><tr><td colspan='2'>[[6bfn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BFN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6BFN FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.26&#8491;</td></tr>

<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DL1:N-[2-methoxy-4-(morpholin-4-yl)phenyl]-6-(1H-pyrazol-5-yl)pyridine-2-carboxamide'>DL1</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6bfn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bfn OCA], [https://pdbe.org/6bfn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6bfn RCSB], [https://www.ebi.ac.uk/pdbsum/6bfn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6bfn ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/IRAK1_HUMAN IRAK1_HUMAN] Systemic lupus erythematosus;Pediatric systemic lupus erythematosus.  

[https://www.uniprot.org/uniprot/IRAK1_HUMAN IRAK1_HUMAN] Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation. Association with MYD88 leads to IRAK1 phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates the interferon regulatory factor 7 (IRF7) to induce its activation and translocation to the nucleus, resulting in transcriptional activation of type I IFN genes, which drive the cell in an antiviral state. When sumoylated, translocates to the nucleus and phosphorylates STAT3.<ref>PMID:11397809</ref> <ref>PMID:12860405</ref> <ref>PMID:14684752</ref> <ref>PMID:15084582</ref> <ref>PMID:15465816</ref> <ref>PMID:15767370</ref> <ref>PMID:17997719</ref> <ref>PMID:20400509</ref>  

 

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Qiao Q]]

[[Category: Wang L]]

[[Category: Wu H]]