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==Cryo-EM structure of human insulin degrading enzyme in complex with insulin== | |||
<SX load='6bf8' size='340' side='right' viewer='molstar' caption='[[6bf8]], [[Resolution|resolution]] 4.20Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6bf8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BF8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6BF8 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.2Å</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6bf8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bf8 OCA], [https://pdbe.org/6bf8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6bf8 RCSB], [https://www.ebi.ac.uk/pdbsum/6bf8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6bf8 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/IDE_HUMAN IDE_HUMAN] Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia.<ref>PMID:10684867</ref> <ref>PMID:17613531</ref> <ref>PMID:18986166</ref> | |||
==See Also== | |||
*[[Insulin-degrading enzyme 3D structures|Insulin-degrading enzyme 3D structures]] | |||
== References == | |||
[[Category: | <references/> | ||
[[Category: | __TOC__ | ||
[[Category: | </SX> | ||
[[Category: Carragher | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Bailey LJ]] | ||
[[Category: | [[Category: Carragher B]] | ||
[[Category: | [[Category: Kossiakoff AA]] | ||
[[Category: | [[Category: Liang WG]] | ||
[[Category: | [[Category: Potter SC]] | ||
[[Category: Tan YZ]] | |||
[[Category: Tang WJ]] | |||
[[Category: Wei H]] | |||
[[Category: Zhang Z]] | |||
Latest revision as of 17:21, 13 March 2024
Cryo-EM structure of human insulin degrading enzyme in complex with insulinCryo-EM structure of human insulin degrading enzyme in complex with insulin
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