6b4w: Difference between revisions

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-'''Unreleased structure'''
-The entry 6b4w is ON HOLD
+==TTK in Complex with Inhibitor==
+<StructureSection load='6b4w' size='340' side='right'caption='[[6b4w]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6b4w]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6B4W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6B4W FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene>, <scene name='pdbligand=CQ7:4-{[4-(cyclopentyloxy)-5-(2-methyl-1,3-benzoxazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino}-3-methoxy-N-methylbenzamide'>CQ7</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6b4w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6b4w OCA], [https://pdbe.org/6b4w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6b4w RCSB], [https://www.ebi.ac.uk/pdbsum/6b4w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6b4w ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/TTK_HUMAN TTK_HUMAN] Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.<ref>PMID:18243099</ref>
-Authors: Delker, S., Chamberlain, P.P.
+==See Also==
+*[[Dual specificity protein kinase 3D structures|Dual specificity protein kinase 3D structures]]
-Description: TTK in Complex with Inhibitor
+== References ==
-[[Category: Unreleased Structures]]
+<references/>
-[[Category: Chamberlain, P.P]]
+__TOC__
-[[Category: Delker, S]]
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Chamberlain PP]]
+[[Category: Delker S]]