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==Crystal structural of Leishmania major pseudoperoxidase==
==Crystal structural of Leishmania major pseudoperoxidase==
<StructureSection load='5via' size='340' side='right' caption='[[5via]], [[Resolution|resolution]] 1.76&Aring;' scene=''>
<StructureSection load='5via' size='340' side='right'caption='[[5via]], [[Resolution|resolution]] 1.76&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5via]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VIA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5VIA FirstGlance]. <br>
<table><tr><td colspan='2'>[[5via]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Leishmania_major Leishmania major]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VIA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5VIA FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.764&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5via FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5via OCA], [http://pdbe.org/5via PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5via RCSB], [http://www.ebi.ac.uk/pdbsum/5via PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5via ProSAT]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5via FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5via OCA], [https://pdbe.org/5via PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5via RCSB], [https://www.ebi.ac.uk/pdbsum/5via PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5via ProSAT]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Function ==
== Publication Abstract from PubMed ==
[https://www.uniprot.org/uniprot/Q4QC30_LEIMA Q4QC30_LEIMA]
Leishmania major pseudoperoxidase (LmPP) is a recently discovered heme protein expressed by the human pathogen. Previous in vivo and in vitro studies suggest that LmPP is a crucial element of the pathogen's defense mechanism against the reactive nitrogen species peroxynitrite produced during the host immune response. To shed light on the potential mechanism of peroxynitrite detoxification, we have determined the 1.76-A X-ray crystal structure of LmPP, revealing a striking degree of homology with heme peroxidases. The most outstanding structural feature is a Cys/His heme coordination, which corroborates previous spectroscopic and mutagenesis studies. We also used a combination of stopped-flow and electron paramagnetic spectroscopies that together suggest that peroxynitrite is not a substrate for LmPP catalysis, leaving the function of LmPP an open question.
 
Crystal structure and functional analysis of Leishmania major pseudoperoxidase.,Chreifi G, Dejam D, Poulos TL J Biol Inorg Chem. 2017 Aug;22(6):919-927. doi: 10.1007/s00775-017-1469-9. Epub, 2017 Jun 5. PMID:28584975<ref>PMID:28584975</ref>
 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 5via" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Chreifi, G]]
[[Category: Large Structures]]
[[Category: Dejam, D]]
[[Category: Leishmania major]]
[[Category: Poulos, T L]]
[[Category: Chreifi G]]
[[Category: Heme protein]]
[[Category: Dejam D]]
[[Category: Oxidoreductase]]
[[Category: Poulos TL]]
[[Category: Peroxidase]]

Latest revision as of 17:10, 13 March 2024

Crystal structural of Leishmania major pseudoperoxidaseCrystal structural of Leishmania major pseudoperoxidase

Structural highlights

5via is a 1 chain structure with sequence from Leishmania major. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.764Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

Q4QC30_LEIMA

5via, resolution 1.76Å

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OCA
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