3des: Difference between revisions

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-[[Image:3des.png|left|200px]]
-{{STRUCTURE_3des|  PDB=3des  |  SCENE=  }}
+==Crystal structure of dipeptide epimerase from Thermotoga maritima complexed with L-Ala-L-Phe dipeptide==
+<StructureSection load='3des' size='340' side='right'caption='[[3des]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
-===Crystal structure of dipeptide epimerase from Thermotoga maritima complexed with L-Ala-L-Phe dipeptide===
+== Structural highlights ==
+<table><tr><td colspan='2'>[[3des]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermotoga_maritima_MSB8 Thermotoga maritima MSB8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DES OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DES FirstGlance]. <br>
-{{ABSTRACT_PUBMED_19000819}}
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ALA:ALANINE'>ALA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PHE:PHENYLALANINE'>PHE</scene></td></tr>
-==About this Structure==
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3des FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3des OCA], [https://pdbe.org/3des PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3des RCSB], [https://www.ebi.ac.uk/pdbsum/3des PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3des ProSAT]</span></td></tr>
-[[3des]] is a 4 chain structure of [[Muconate cycloisomerase]] with sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima_msb8 Thermotoga maritima msb8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DES OCA].
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/AEEP_THEMA AEEP_THEMA] Catalyzes the epimerization of L-Ala-D-Glu to L-Ala-L-Glu and has probably a role in the metabolism of the murein peptide, of which L-Ala-D-Glu is a component. Is also able to catalyze the reverse reaction and the epimerization of a broad range of other dipeptides; is most efficient with L-Ala-D/L-Phe, L-Ala-D/L-Tyr, and L-Ala-D/L-His.<ref>PMID:19000819</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/de/3des_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3des ConSurf].
+<div style="clear:both"></div>
 ==See Also==
 *[[Muconate cycloisomerase|Muconate cycloisomerase]]
+== References ==
-==Reference==
+<references/>
-<ref group="xtra">PMID:019000819</ref><references group="xtra"/>
+__TOC__
-[[Category: Thermotoga maritima msb8]]
+</StructureSection>
-[[Category: Almo, S C.]]
+[[Category: Large Structures]]
-[[Category: Fedorov, A A.]]
+[[Category: Thermotoga maritima MSB8]]
-[[Category: Fedorov, E V.]]
+[[Category: Almo SC]]
-[[Category: Gerlt, J A.]]
+[[Category: Fedorov AA]]
-[[Category: Imker, H J.]]
+[[Category: Fedorov EV]]
-[[Category: Dipeptide epimerase]]
+[[Category: Gerlt JA]]
-[[Category: Enzymatic function]]
+[[Category: Imker HJ]]
-[[Category: Isomerase]]
-[[Category: Thermotoga maritima]]