3c0g: Difference between revisions

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-{{Seed}}
-[[Image:3c0g.png|left|200px]]
-<!--
+==CASK CaM-Kinase Domain- 3'-AMP complex, P1 form==
-The line below this paragraph, containing "STRUCTURE_3c0g", creates the "Structure Box" on the page.
+<StructureSection load='3c0g' size='340' side='right'caption='[[3c0g]], [[Resolution|resolution]] 2.19&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[3c0g]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C0G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3C0G FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.19&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3AM:[(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-4-HYDROXY-2-(HYDROXYMETHYL)OXOLAN-3-YL]+DIHYDROGEN+PHOSPHATE'>3AM</scene></td></tr>
-{{STRUCTURE_3c0g|  PDB=3c0g  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3c0g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3c0g OCA], [https://pdbe.org/3c0g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3c0g RCSB], [https://www.ebi.ac.uk/pdbsum/3c0g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3c0g ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/CSKP_HUMAN CSKP_HUMAN] Defects in CASK are the cause of mental retardation and microcephaly with pontine and cerebellar hypoplasia (MICPCH) [MIM:[https://omim.org/entry/300749 300749]. A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Patients with mental retardation X-linked CASK-related can manifest a severe phenotype consisting of severe intellectual deficit, congenital or postnatal microcephaly, disproportionate brainstem and cerebellar hypoplasia. A milder phenotype consists of mental retardation alone or associated with nystagmus.<ref>PMID:19165920</ref>   Defects in CASK are the cause of FG syndrome type 4 (FGS4) [MIM:[https://omim.org/entry/300422 300422]. FG syndrome (FGS) is an X-linked disorder characterized by mental retardation, relative macrocephaly, hypotonia and constipation.<ref>PMID:19200522</ref>
+== Function ==
+[https://www.uniprot.org/uniprot/CSKP_HUMAN CSKP_HUMAN] Multidomain scaffolding protein with a role in synaptic transmembrane protein anchoring and ion channel trafficking. Contributes to neural development and regulation of gene expression via interaction with the transcription factor TRB1. Binds to cell-surface proteins, including amyloid precursor protein, neurexins and syndecans. May mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and with the actin/spectrin-binding protein 4.1.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c0/3c0g_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3c0g ConSurf].
+<div style="clear:both"></div>
-===CASK CaM-Kinase Domain- 3'-AMP complex, P1 form===
+==See Also==
+*[[Calcium/calmodulin dependent protein kinase 3D structures|Calcium/calmodulin dependent protein kinase 3D structures]]
+== References ==
-<!--
+<references/>
-The line below this paragraph, {{ABSTRACT_PUBMED_18423203}}, adds the Publication Abstract to the page
+__TOC__
-(as it appears on PubMed at http://www.pubmed.gov), where 18423203 is the PubMed ID number.
+</StructureSection>
--->
-{{ABSTRACT_PUBMED_18423203}}
-==Disease==
-Known disease associated with this structure: Mental retardation and microcephaly with pontine and cerebellar hypoplasia OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=300172 300172]]
-==About this Structure==
-C0G is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C0G OCA].
-==Reference==
-<ref group="xtra">PMID:18423203</ref><references group="xtra"/>
 [[Category: Homo sapiens]]
-[[Category: Non-specific serine/threonine protein kinase]]
+[[Category: Large Structures]]
-[[Category: Wahl, M C.]]
+[[Category: Wahl MC]]
-[[Category: Alternative splicing]]
-[[Category: Atp-binding]]
-[[Category: Ca2+/calmodulin dependent protein kinase]]
-[[Category: Calmodulin-binding]]
-[[Category: Cask]]
-[[Category: Cytoplasm]]
-[[Category: Magnesium]]
-[[Category: Maguk]]
-[[Category: Membrane-associated guanylate kinase]]
-[[Category: Metal-binding]]
-[[Category: Mg2+]]
-[[Category: Neurexin]]
-[[Category: Nucleotide-binding]]
-[[Category: Nucleus]]
-[[Category: Pseudokinase]]
-[[Category: Serine/threonine-protein kinase]]
-[[Category: Sh3 domain]]
-[[Category: Synaptic plasticity]]
-[[Category: Transferase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 13:29:23 2009''