3b0f: Difference between revisions
New page: '''Unreleased structure''' The entry 3b0f is ON HOLD Authors: Isogai, S., Morimoto, D., Arita, K., Unzai, S., Tenno, T., Hasegawa, J., Sou, Y., Komatsu, M., Tanaka, K., Shirakawa, M., T... |
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==Crystal structure of the UBA domain of p62 and its interaction with ubiquitin== | |||
<StructureSection load='3b0f' size='340' side='right'caption='[[3b0f]], [[Resolution|resolution]] 1.40Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3b0f]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B0F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3B0F FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3b0f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3b0f OCA], [https://pdbe.org/3b0f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3b0f RCSB], [https://www.ebi.ac.uk/pdbsum/3b0f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3b0f ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/SQSTM_MOUSE SQSTM_MOUSE] Required both for the formation and autophagic degradation of polyubiquitin-containing bodies, called ALIS (aggresome-like induced structures). Links ALIS to the autophagic machinery via direct interaction with MAP1 LC3 family members. May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. May play a role in titin/TTN downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. May be involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels. Adapter that mediates the interaction between TRAF6 and CYLD.<ref>PMID:14960283</ref> <ref>PMID:18382763</ref> | |||
==See Also== | |||
*[[Sequestosome|Sequestosome]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Mus musculus]] | |||
[[Category: Arita K]] | |||
[[Category: Hasegawa J]] | |||
[[Category: Isogai S]] | |||
[[Category: Komatsu M]] | |||
[[Category: Morimoto D]] | |||
[[Category: Shirakawa M]] | |||
[[Category: Sou Y]] | |||
[[Category: Tanaka K]] | |||
[[Category: Tenno T]] | |||
[[Category: Tochio H]] | |||
[[Category: Unzai S]] | |||