3b0d: Difference between revisions

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'''Unreleased structure'''


The entry 3b0d is ON HOLD  until Paper Publication
==Crystal structure of the chicken CENP-T histone fold/CENP-W complex, crystal form II==
<StructureSection load='3b0d' size='340' side='right'caption='[[3b0d]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3b0d]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B0D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3B0D FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.197&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3b0d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3b0d OCA], [https://pdbe.org/3b0d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3b0d RCSB], [https://www.ebi.ac.uk/pdbsum/3b0d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3b0d ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CENPT_CHICK CENPT_CHICK] Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation (By similarity). The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres (By similarity). Part of a nucleosome-associated complex that binds specifically to histone H3-containing nucleosomes at the centromere, as opposed to nucleosomes containing CENPA. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. CENPT has a fundamental role in kinetochore assembly and function. It is one of the inner kinetochore proteins, with most further proteins binding downstream. Required for normal chromosome organization and normal progress through mitosis.<ref>PMID:19070575</ref> <ref>PMID:22304917</ref>


Authors: Nishino, T., Takeuchi, K., Gascoigne, K.E., Suzuki, A., Hori, T., Oyama, T., Morikawa, K., Cheeseman, I.M., Fukagawa, T.
==See Also==
 
*[[Centromere protein 3D structure|Centromere protein 3D structure]]
Description: Crystal structure of the chicken CENP-T histone fold/CENP-W complex, crystal form II
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Gallus gallus]]
[[Category: Large Structures]]
[[Category: Cheeseman IM]]
[[Category: Fukagawa T]]
[[Category: Gascoigne KE]]
[[Category: Hori T]]
[[Category: Morikawa K]]
[[Category: Nishino T]]
[[Category: Oyama T]]
[[Category: Suzuki A]]
[[Category: Takeuchi K]]

Latest revision as of 17:03, 13 March 2024

Crystal structure of the chicken CENP-T histone fold/CENP-W complex, crystal form IICrystal structure of the chicken CENP-T histone fold/CENP-W complex, crystal form II

Structural highlights

3b0d is a 4 chain structure with sequence from Gallus gallus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.197Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

CENPT_CHICK Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation (By similarity). The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres (By similarity). Part of a nucleosome-associated complex that binds specifically to histone H3-containing nucleosomes at the centromere, as opposed to nucleosomes containing CENPA. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. CENPT has a fundamental role in kinetochore assembly and function. It is one of the inner kinetochore proteins, with most further proteins binding downstream. Required for normal chromosome organization and normal progress through mitosis.[1] [2]

See Also

References

  1. ↑ Hori T, Amano M, Suzuki A, Backer CB, Welburn JP, Dong Y, McEwen BF, Shang WH, Suzuki E, Okawa K, Cheeseman IM, Fukagawa T. CCAN makes multiple contacts with centromeric DNA to provide distinct pathways to the outer kinetochore. Cell. 2008 Dec 12;135(6):1039-52. doi: 10.1016/j.cell.2008.10.019. PMID:19070575 doi:10.1016/j.cell.2008.10.019
  2. ↑ Nishino T, Takeuchi K, Gascoigne KE, Suzuki A, Hori T, Oyama T, Morikawa K, Cheeseman IM, Fukagawa T. CENP-T-W-S-X Forms a Unique Centromeric Chromatin Structure with a Histone-like Fold. Cell. 2012 Feb 3;148(3):487-501. PMID:22304917 doi:10.1016/j.cell.2011.11.061

3b0d, resolution 2.20Å

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