3ax1: Difference between revisions

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{{STRUCTURE_3ax1|  PDB=3ax1  |  SCENE=  }}
===Molecular insights into miRNA processing by Arabidopsis Serrate===
{{ABSTRACT_PUBMED_21685453}}


==About this Structure==
==Molecular insights into miRNA processing by Arabidopsis Serrate==
[[3ax1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AX1 OCA].  
<StructureSection load='3ax1' size='340' side='right'caption='[[3ax1]], [[Resolution|resolution]] 2.74&Aring;' scene=''>
 
== Structural highlights ==
==Reference==
<table><tr><td colspan='2'>[[3ax1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AX1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3AX1 FirstGlance]. <br>
<ref group="xtra">PMID:021685453</ref><references group="xtra"/><references/>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.74&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ax1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ax1 OCA], [https://pdbe.org/3ax1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ax1 RCSB], [https://www.ebi.ac.uk/pdbsum/3ax1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ax1 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SRRT_ARATH SRRT_ARATH] Acts as a mediator between the cap-binding complex (CBC) and both the pre-mRNA splicing and primary microRNAs (miRNAs) processing machinery. Required for proper processing of primary miRNAs to miRNAs, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs. Does not participate in sense post-transcriptional gene silencing. Acts as a regulator of meristem activity and adaxial leaf fate via the miRNA gene-silencing pathway by regulating the expression of PHB and by limiting the competence of shoot tissue to respond to KNOX expression. Its function is however not limited to miRNA-mediated repression of leaf polarity genes, but rather acts as a general regulator of primary microRNAs processing. Also critical for the accumulation of the trans-acting small interfering RNA (ta-siRNA). Required for pre-mRNA splicing.<ref>PMID:16222298</ref> <ref>PMID:16977334</ref> <ref>PMID:16889646</ref> <ref>PMID:18632569</ref> <ref>PMID:18550839</ref>  
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Arabidopsis thaliana]]
[[Category: Arabidopsis thaliana]]
[[Category: Chen, H Y.]]
[[Category: Large Structures]]
[[Category: Machida, S.]]
[[Category: Chen HY]]
[[Category: Yuan, Y A.]]
[[Category: Machida S]]
[[Category: Mirna processing]]
[[Category: Yuan YA]]
[[Category: Protein binding]]
[[Category: Serrate]]

Latest revision as of 17:02, 13 March 2024

Molecular insights into miRNA processing by Arabidopsis SerrateMolecular insights into miRNA processing by Arabidopsis Serrate

Structural highlights

3ax1 is a 1 chain structure with sequence from Arabidopsis thaliana. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.74Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

SRRT_ARATH Acts as a mediator between the cap-binding complex (CBC) and both the pre-mRNA splicing and primary microRNAs (miRNAs) processing machinery. Required for proper processing of primary miRNAs to miRNAs, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs. Does not participate in sense post-transcriptional gene silencing. Acts as a regulator of meristem activity and adaxial leaf fate via the miRNA gene-silencing pathway by regulating the expression of PHB and by limiting the competence of shoot tissue to respond to KNOX expression. Its function is however not limited to miRNA-mediated repression of leaf polarity genes, but rather acts as a general regulator of primary microRNAs processing. Also critical for the accumulation of the trans-acting small interfering RNA (ta-siRNA). Required for pre-mRNA splicing.[1] [2] [3] [4] [5]

References

  1. ↑ Grigg SP, Canales C, Hay A, Tsiantis M. SERRATE coordinates shoot meristem function and leaf axial patterning in Arabidopsis. Nature. 2005 Oct 13;437(7061):1022-6. PMID:16222298 doi:10.1038/nature04052
  2. ↑ Lobbes D, Rallapalli G, Schmidt DD, Martin C, Clarke J. SERRATE: a new player on the plant microRNA scene. EMBO Rep. 2006 Oct;7(10):1052-8. Epub 2006 Sep 15. PMID:16977334 doi:10.1038/sj.embor.7400806
  3. ↑ Yang L, Liu Z, Lu F, Dong A, Huang H. SERRATE is a novel nuclear regulator in primary microRNA processing in Arabidopsis. Plant J. 2006 Sep;47(6):841-50. Epub 2006 Aug 2. PMID:16889646 doi:10.1111/j.1365-313X.2006.02835.x
  4. ↑ Dong Z, Han MH, Fedoroff N. The RNA-binding proteins HYL1 and SE promote accurate in vitro processing of pri-miRNA by DCL1. Proc Natl Acad Sci U S A. 2008 Jul 22;105(29):9970-5. doi:, 10.1073/pnas.0803356105. Epub 2008 Jul 16. PMID:18632569 doi:10.1073/pnas.0803356105
  5. ↑ Laubinger S, Sachsenberg T, Zeller G, Busch W, Lohmann JU, Ratsch G, Weigel D. Dual roles of the nuclear cap-binding complex and SERRATE in pre-mRNA splicing and microRNA processing in Arabidopsis thaliana. Proc Natl Acad Sci U S A. 2008 Jun 24;105(25):8795-800. doi:, 10.1073/pnas.0802493105. Epub 2008 Jun 12. PMID:18550839 doi:10.1073/pnas.0802493105

3ax1, resolution 2.74Å

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