3a06: Difference between revisions
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==Crystal structure of DXR from Thermooga maritia, in complex with fosmidomycin and NADPH== | |||
<StructureSection load='3a06' size='340' side='right'caption='[[3a06]], [[Resolution|resolution]] 2.00Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3a06]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A06 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3A06 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FOM:3-[FORMYL(HYDROXY)AMINO]PROPYLPHOSPHONIC+ACID'>FOM</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3a06 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3a06 OCA], [https://pdbe.org/3a06 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3a06 RCSB], [https://www.ebi.ac.uk/pdbsum/3a06 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3a06 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/DXR_THEMA DXR_THEMA] Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP). | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a0/3a06_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3a06 ConSurf]. | |||
<div style="clear:both"></div> | |||
== | ==See Also== | ||
*[[DXP reductoisomerase 3D Structures|DXP reductoisomerase 3D Structures]] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[ | |||
[[Category: | |||
[[Category: Thermotoga maritima]] | [[Category: Thermotoga maritima]] | ||
[[Category: Noguchi | [[Category: Noguchi K]] | ||
[[Category: Ohsawa | [[Category: Ohsawa K]] | ||
[[Category: Ohtaki | [[Category: Ohtaki A]] | ||
[[Category: Sasaki | [[Category: Sasaki Y]] | ||
[[Category: Takenoya | [[Category: Takenoya M]] | ||
[[Category: Yajima | [[Category: Yajima S]] | ||
[[Category: Yohda | [[Category: Yohda M]] | ||
Latest revision as of 16:59, 13 March 2024
Crystal structure of DXR from Thermooga maritia, in complex with fosmidomycin and NADPHCrystal structure of DXR from Thermooga maritia, in complex with fosmidomycin and NADPH
Structural highlights
FunctionDXR_THEMA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP). Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. See Also |
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