2zzq: Difference between revisions

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-[[Image:2zzq.png|left|200px]]
-{{STRUCTURE_2zzq|  PDB=2zzq  |  SCENE=  }}
+==Crystal structure analysis of the HEV capsid protein, PORF2==
+<StructureSection load='2zzq' size='340' side='right'caption='[[2zzq]], [[Resolution|resolution]] 3.81&Aring;' scene=''>
-===Crystal structure analysis of the HEV capsid protein, PORF2===
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2zzq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Hepatitis_E_virus_(strain_Myanmar) Hepatitis E virus (strain Myanmar)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZZQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZZQ FirstGlance]. <br>
-{{ABSTRACT_PUBMED_020720013}}
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.81&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zzq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zzq OCA], [https://pdbe.org/2zzq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zzq RCSB], [https://www.ebi.ac.uk/pdbsum/2zzq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zzq ProSAT]</span></td></tr>
-==About this Structure==
+</table>
-[[2zzq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Hepatitis_e_virus Hepatitis e virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZZQ OCA].
+== Function ==
+[https://www.uniprot.org/uniprot/CAPSD_HEVBU CAPSD_HEVBU] Plays a role in the inhibition of host antibody-mediated neutralization without blocking viral cell entry.[UniProtKB:Q9YLQ9]  Forms an icosahedral capsid with a T=1 symmetry and a 34 nm diameter. The capsid is composed of 60 copies linked to each other. Binds to the 5' end of the genomic RNA to mediate genome encapsidation (PubMed:14671114, PubMed:15557331). Binds to heparin surface proteoglycans (HSPGs) to mediate viral entry (By similarity). Additionally, the interactions with host ASGR1 and ASGR2 facilitate viral infection of hepatocytes (By similarity). Inhibits IFN production by blocking host TBK1-induced IRF3 phosphorylation (By similarity). The nuclear form probably modulates host gene expression (By similarity).[UniProtKB:P33426][UniProtKB:Q81871]<ref>PMID:14671114</ref> <ref>PMID:15557331</ref> [https://www.uniprot.org/uniprot/ORF3_HEVBU ORF3_HEVBU] May act as a viral regulatory protein involved in the modulation of mitogenic signaling pathways. May be involved in virion morphogenesis and viral pathogenesis. Expedites the processing and secretion of AMBP from the hepatocyte (By similarity).
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zz/2zzq_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2zzq ConSurf].
+<div style="clear:both"></div>
 ==See Also==
-*[[Virus coat protein|Virus coat protein]]
+*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
+== References ==
-==Reference==
+<references/>
-<ref group="xtra">PMID:020720013</ref><references group="xtra"/>
+__TOC__
-[[Category: Hepatitis e virus]]
+</StructureSection>
-[[Category: Cheng, R H.]]
+[[Category: Large Structures]]
-[[Category: Higashiura, A.]]
+[[Category: Cheng RH]]
-[[Category: Li, T C.]]
+[[Category: Higashiura A]]
-[[Category: Miyamura, T.]]
+[[Category: Li T-C]]
-[[Category: Miyazaki, N.]]
+[[Category: Miyamura T]]
-[[Category: Nakagawa, A.]]
+[[Category: Miyazaki N]]
-[[Category: Takeda, N.]]
+[[Category: Nakagawa A]]
-[[Category: Tsukihara, T.]]
+[[Category: Takeda N]]
-[[Category: Wang, C Y.]]
+[[Category: Tsukihara T]]
-[[Category: Xing, L.]]
+[[Category: Wang C-Y]]
-[[Category: Hepatitis e virus]]
+[[Category: Xing L]]
-[[Category: Hev]]
-[[Category: Host-virus interaction]]
-[[Category: Phosphoprotein]]
-[[Category: Viral capsid protein]]
-[[Category: Virus]]
-[[Category: Virus-like particle]]