2zhg: Difference between revisions

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-[[Image:2zhg.png|left|200px]]
-{{STRUCTURE_2zhg|  PDB=2zhg  |  SCENE=  }}
+==Crystal structure of SoxR in complex with DNA==
+<StructureSection load='2zhg' size='340' side='right'caption='[[2zhg]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2zhg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZHG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZHG FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DTT:2,3-DIHYDROXY-1,4-DITHIOBUTANE'>DTT</scene>, <scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zhg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zhg OCA], [https://pdbe.org/2zhg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zhg RCSB], [https://www.ebi.ac.uk/pdbsum/2zhg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zhg ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/SOXR_ECOLI SOXR_ECOLI] Activates the transcription of the soxS gene which itself controls the superoxide response regulon. SoxR contains a 2Fe-2S iron-sulfur cluster that may act as a redox sensor system that recognizes superoxide. The variable redox state of the Fe-S cluster is employed in vivo to modulate the transcriptional activity of SoxR in response to specific types of oxidative stress. Upon reduction of 2Fe-2S cluster, SoxR reversibly loses its transcriptional activity, but retains its DNA binding affinity.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zh/2zhg_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2zhg ConSurf].
+<div style="clear:both"></div>
-===Crystal structure of SoxR in complex with DNA===
+==See Also==
+*[[Transcriptional activator 3D structures|Transcriptional activator 3D structures]]
-{{ABSTRACT_PUBMED_18334645}}
+__TOC__
+</StructureSection>
-==About this Structure==
+[[Category: Escherichia coli K-12]]
-[[2zhg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZHG OCA].
+[[Category: Large Structures]]
+[[Category: Kita A]]
-==Reference==
+[[Category: Kobayashi K]]
-<ref group="xtra">PMID:018334645</ref><references group="xtra"/>
+[[Category: Miki K]]
-[[Category: Escherichia coli]]
+[[Category: Watanabe S]]
-[[Category: Kita, A.]]
-[[Category: Kobayashi, K.]]
-[[Category: Miki, K.]]
-[[Category: Watanabe, S.]]
-[[Category: Activator]]
-[[Category: Dna-binding]]
-[[Category: Iron]]
-[[Category: Iron-sulfur]]
-[[Category: Merr family]]
-[[Category: Metal-binding]]
-[[Category: Oxidative stress]]
-[[Category: Transcription]]
-[[Category: Transcription regulation]]
-[[Category: Transcription-dna complex]]