2z5h: Difference between revisions

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-[[Image:2z5h.png|left|200px]]
-<!--
+==Crystal structure of the head-to-tail junction of tropomyosin complexed with a fragment of TnT==
-The line below this paragraph, containing "STRUCTURE_2z5h", creates the "Structure Box" on the page.
+<StructureSection load='2z5h' size='340' side='right'caption='[[2z5h]], [[Resolution|resolution]] 2.89&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[2z5h]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus], [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus] and [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z5H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Z5H FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.89&#8491;</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2z5h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z5h OCA], [https://pdbe.org/2z5h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2z5h RCSB], [https://www.ebi.ac.uk/pdbsum/2z5h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2z5h ProSAT]</span></td></tr>
-{{STRUCTURE_2z5h|  PDB=2z5h  |  SCENE=  }}
+</table>
+== Function ==
-===Crystal structure of the head-to-tail junction of tropomyosin complexed with a fragment of TnT===
+[https://www.uniprot.org/uniprot/GCN4_YEAST GCN4_YEAST] Is a transcription factor that is responsible for the activation of more than 30 genes required for amino acid or for purine biosynthesis in response to amino acid or purine starvation. Binds and recognize the DNA sequence: 5'-TGA[CG]TCA-3'.[https://www.uniprot.org/uniprot/TPM1_RABIT TPM1_RABIT] Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
-==About this Structure==
+Check<jmol>
-[[2z5h]] is a 10 chain structure of [[Tropomyosin]] and [[Troponin]] with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus], [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus,_saccharomyces_cerevisiae Oryctolagus cuniculus, saccharomyces cerevisiae] and [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae,_oryctolagus_cuniculus Saccharomyces cerevisiae, oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z5H OCA].
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z5/2z5h_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2z5h ConSurf].
+<div style="clear:both"></div>
 ==See Also==
-*[[Tropomyosin]]
+*[[Gcn4 3D Structures|Gcn4 3D Structures]]
-*[[Troponin]]
+*[[Gnc4 3D Structures|Gnc4 3D Structures]]
+*[[Tropomyosin 3D structures|Tropomyosin 3D structures]]
+*[[Troponin 3D structures|Troponin 3D structures]]
+__TOC__
+</StructureSection>
 [[Category: Gallus gallus]]
-[[Category: Oryctolagus cuniculus, saccharomyces cerevisiae]]
+[[Category: Large Structures]]
-[[Category: Saccharomyces cerevisiae, oryctolagus cuniculus]]
+[[Category: Oryctolagus cuniculus]]
-[[Category: Igarashi, N.]]
+[[Category: Saccharomyces cerevisiae]]
-[[Category: Kudou, N.]]
+[[Category: Igarashi N]]
-[[Category: Murakami, K.]]
+[[Category: Kudou N]]
-[[Category: Nozawa, K.]]
+[[Category: Murakami K]]
-[[Category: Shirakihara, Y.]]
+[[Category: Nozawa K]]
-[[Category: Stewart, M.]]
+[[Category: Shirakihara Y]]
-[[Category: Tomii, K.]]
+[[Category: Stewart M]]
-[[Category: Wakabayashi, T.]]
+[[Category: Tomii K]]
-[[Category: Wakatsuki, S.]]
+[[Category: Wakabayashi T]]
-[[Category: Yasunaga, T.]]
+[[Category: Wakatsuki S]]
-[[Category: Actin]]
+[[Category: Yasunaga T]]
-[[Category: Cardiomyopathy]]
-[[Category: Coiled coil]]
-[[Category: Contractile protein]]
-[[Category: Cytoskeleton]]
-[[Category: Four-helix bundle]]
-[[Category: Tropomyosin]]
-[[Category: Troponin]]