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[[Image:2ri1.jpg|left|200px]]


{{Structure
==Crystal Structure of glucosamine 6-phosphate deaminase (NagB) with GlcN6P from S. mutans==
|PDB= 2ri1 |SIZE=350|CAPTION= <scene name='initialview01'>2ri1</scene>, resolution 2.030&Aring;
<StructureSection load='2ri1' size='340' side='right'caption='[[2ri1]], [[Resolution|resolution]] 2.03&Aring;' scene=''>
|SITE= <scene name='pdbsite=AC1:Glp+Binding+Site+For+Residue+A+234'>AC1</scene>, <scene name='pdbsite=AC2:Glp+Binding+Site+For+Residue+B+234'>AC2</scene>, <scene name='pdbsite=AC3:Btb+Binding+Site+For+Residue+B+235'>AC3</scene> and <scene name='pdbsite=AC4:Btb+Binding+Site+For+Residue+A+235'>AC4</scene>
== Structural highlights ==
|LIGAND= <scene name='pdbligand=BTB:2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>BTB</scene>, <scene name='pdbligand=GLP:GLUCOSAMINE+6-PHOSPHATE'>GLP</scene>
<table><tr><td colspan='2'>[[2ri1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_mutans Streptococcus mutans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RI1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RI1 FirstGlance]. <br>
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucosamine-6-phosphate_deaminase Glucosamine-6-phosphate deaminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.99.6 3.5.99.6] </span>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.03&#8491;</td></tr>
|GENE= SMU.636 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1309 Streptococcus mutans])
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BTB:2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>BTB</scene>, <scene name='pdbligand=GLP:GLUCOSAMINE+6-PHOSPHATE'>GLP</scene></td></tr>
|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01399 GlcN6P_deaminase]</span>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ri1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ri1 OCA], [https://pdbe.org/2ri1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ri1 RCSB], [https://www.ebi.ac.uk/pdbsum/2ri1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ri1 ProSAT]</span></td></tr>
|RELATEDENTRY=[[2ri0|2RI0]]
</table>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ri1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ri1 OCA], [http://www.ebi.ac.uk/pdbsum/2ri1 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2ri1 RCSB]</span>
== Function ==
}}
[https://www.uniprot.org/uniprot/NAGB_STRMU NAGB_STRMU] Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ri/2ri1_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ri1 ConSurf].
<div style="clear:both"></div>


'''Crystal Structure of glucosamine 6-phosphate deaminase (NagB) with GlcN6P from S. mutans'''
==See Also==
 
*[[Deaminase 3D structures|Deaminase 3D structures]]
 
__TOC__
==About this Structure==
</StructureSection>
2RI1 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Streptococcus_mutans Streptococcus mutans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RI1 OCA].
[[Category: Large Structures]]
[[Category: Glucosamine-6-phosphate deaminase]]
[[Category: Single protein]]
[[Category: Streptococcus mutans]]
[[Category: Streptococcus mutans]]
[[Category: Li, D.]]
[[Category: Li D]]
[[Category: Liu, C.]]
[[Category: Liu C]]
[[Category: Su, X D.]]
[[Category: Su XD]]
[[Category: carbohydrate metabolism]]
[[Category: glucosamine 6-phosphate (glcn6p)]]
[[Category: glucosamine 6-phosphate deaminase]]
[[Category: hydrolase]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:00:34 2008''

Latest revision as of 16:54, 13 March 2024

Crystal Structure of glucosamine 6-phosphate deaminase (NagB) with GlcN6P from S. mutansCrystal Structure of glucosamine 6-phosphate deaminase (NagB) with GlcN6P from S. mutans

Structural highlights

2ri1 is a 2 chain structure with sequence from Streptococcus mutans. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.03Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

NAGB_STRMU Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity).

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

2ri1, resolution 2.03Å

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