2g6f: Difference between revisions

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[[Image:2g6f.png|left|200px]]


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==Crystal Structure of the SH3 Domain of betaPIX in Complex with a High Affinity Peptide from PAK2==
The line below this paragraph, containing "STRUCTURE_2g6f", creates the "Structure Box" on the page.
<StructureSection load='2g6f' size='340' side='right'caption='[[2g6f]], [[Resolution|resolution]] 0.92&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2g6f]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G6F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2G6F FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 0.92&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NCO:COBALT+HEXAMMINE(III)'>NCO</scene></td></tr>
{{STRUCTURE_2g6f| PDB=2g6f |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2g6f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g6f OCA], [https://pdbe.org/2g6f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2g6f RCSB], [https://www.ebi.ac.uk/pdbsum/2g6f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2g6f ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ARHG7_RAT ARHG7_RAT] Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions. May function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons (By similarity).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g6/2g6f_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2g6f ConSurf].
<div style="clear:both"></div>


===Crystal Structure of the SH3 Domain of betaPIX in Complex with a High Affinity Peptide from PAK2===
==See Also==
 
*[[Rho guanine nucleotide exchange factor 3D structures|Rho guanine nucleotide exchange factor 3D structures]]
 
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[[Category: Large Structures]]
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{{ABSTRACT_PUBMED_16527308}}
 
==About this Structure==
2G6F is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G6F OCA].
 
==Reference==
Crystal structure of the SH3 domain of betaPIX in complex with a high affinity peptide from PAK2., Hoelz A, Janz JM, Lawrie SD, Corwin B, Lee A, Sakmar TP, J Mol Biol. 2006 Apr 28;358(2):509-22. Epub 2006 Feb 28. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16527308 16527308]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
[[Category: Single protein]]
[[Category: Hoelz A]]
[[Category: Hoelz, A.]]
[[Category: Peptide interaction]]
[[Category: Sh3 domain]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 18:02:22 2008''

Latest revision as of 16:51, 13 March 2024

Crystal Structure of the SH3 Domain of betaPIX in Complex with a High Affinity Peptide from PAK2Crystal Structure of the SH3 Domain of betaPIX in Complex with a High Affinity Peptide from PAK2

Structural highlights

2g6f is a 1 chain structure with sequence from Rattus norvegicus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 0.92Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

ARHG7_RAT Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions. May function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons (By similarity).

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

2g6f, resolution 0.92Å

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