2g62: Difference between revisions

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-[[Image:2g62.gif|left|200px]]
-<!--
+==Crystal structure of human PTPA==
-The line below this paragraph, containing "STRUCTURE_2g62", creates the "Structure Box" on the page.
+<StructureSection load='2g62' size='340' side='right'caption='[[2g62]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[2g62]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G62 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2G62 FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-{{STRUCTURE_2g62|  PDB=2g62  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2g62 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g62 OCA], [https://pdbe.org/2g62 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2g62 RCSB], [https://www.ebi.ac.uk/pdbsum/2g62 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2g62 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/PTPA_HUMAN PTPA_HUMAN] PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for serine/threonine-protein phosphatase 2A (PP2A) modulating its activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a proposed direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2A(i)) in presence of ATP and Mg(2+) (By similarity). Reversibly stimulates the variable phosphotyrosyl phosphatase activity of PP2A core heterodimer PP2A(D) in presence of ATP and Mg(2+) (in vitro). The phosphotyrosyl phosphatase activity is dependent of an ATPase activity of the PP2A(D):PPP2R4 complex. Is involved in apoptosis; the function appears to be independent from PP2A.<ref>PMID:17333320</ref> <ref>PMID:16916641</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g6/2g62_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2g62 ConSurf].
+<div style="clear:both"></div>
-'''Crystal structure of human PTPA'''
+==See Also==
+*[[Protein phosphatase 3D structures|Protein phosphatase 3D structures]]
+== References ==
-==About this Structure==
+<references/>
-G62 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G62 OCA].
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Single protein]]
+[[Category: Large Structures]]
-[[Category: Arrowsmith, C.]]
+[[Category: Arrowsmith C]]
-[[Category: Berg, S Van Den.]]
+[[Category: Berglund H]]
-[[Category: Berglund, H.]]
+[[Category: Collins R]]
-[[Category: Collins, R.]]
+[[Category: Edwards A]]
-[[Category: Edwards, A.]]
+[[Category: Ehn M]]
-[[Category: Ehn, M.]]
+[[Category: Flodin S]]
-[[Category: Flodin, S.]]
+[[Category: Flores A]]
-[[Category: Flores, A.]]
+[[Category: Graslund S]]
-[[Category: G Thorsell, A.]]
+[[Category: Hallberg BM]]
-[[Category: Graslund, S.]]
+[[Category: Hammarstrom M]]
-[[Category: Hallberg, B M.]]
+[[Category: Hogbom M]]
-[[Category: Hammarstrom, M.]]
+[[Category: Holmberg Schiavone L]]
-[[Category: Hogbom, M.]]
+[[Category: Kotenyova T]]
-[[Category: Kotenyova, T.]]
+[[Category: Magnusdottir A]]
-[[Category: Magnusdottir, A.]]
+[[Category: Nilsson-Ehle P]]
-[[Category: Nilsson-Ehle, P.]]
+[[Category: Nordlund P]]
-[[Category: Nordlund, P.]]
+[[Category: Nyman T]]
-[[Category: Nyman, T.]]
+[[Category: Ogg D]]
-[[Category: Ogg, D.]]
+[[Category: Persson C]]
-[[Category: Persson, C.]]
+[[Category: Sagemark J]]
-[[Category: Sagemark, J.]]
+[[Category: Stenmark P]]
-[[Category: Schiavone, L Holmberg.]]
+[[Category: Sundstrom M]]
-[[Category: Stenmark, P.]]
+[[Category: Thorsell AG]]
-[[Category: Sundstrom, M.]]
+[[Category: Van Den Berg S]]
-[[Category: Wallden, K.]]
+[[Category: Wallden K]]
-[[Category: Weigelt, J.]]
+[[Category: Weigelt J]]
-[[Category: Mgc2184]]
-[[Category: Pp2a]]
-[[Category: Ppp2r4]]
-[[Category: Pr53]]
-[[Category: Protein phosphatase 2a]]
-[[Category: Ptpa]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 04:43:35 2008''