2fmx: Difference between revisions

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[[Image:2fmx.png|left|200px]]


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==An open conformation of switch I revealed by Sar1-GDP crystal structure at low Mg(2+)==
The line below this paragraph, containing "STRUCTURE_2fmx", creates the "Structure Box" on the page.
<StructureSection load='2fmx' size='340' side='right'caption='[[2fmx]], [[Resolution|resolution]] 1.82&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2fmx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Cricetulus_griseus Cricetulus griseus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FMX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FMX FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.82&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
{{STRUCTURE_2fmx| PDB=2fmx |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fmx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fmx OCA], [https://pdbe.org/2fmx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fmx RCSB], [https://www.ebi.ac.uk/pdbsum/2fmx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fmx ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SAR1B_CRIGR SAR1B_CRIGR] Involved in transport from the endoplasmic reticulum to the Golgi apparatus. Activated by the guanine nucleotide exchange factor PREB. Involved in the selection of the protein cargo and the assembly of the COPII coat complex.<ref>PMID:8138575</ref> <ref>PMID:11149932</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fm/2fmx_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2fmx ConSurf].
<div style="clear:both"></div>


===An open conformation of switch I revealed by Sar1-GDP crystal structure at low Mg(2+)===
==See Also==
 
*[[GTP-binding protein 3D structures|GTP-binding protein 3D structures]]
 
== References ==
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{{ABSTRACT_PUBMED_16899220}}
 
==About this Structure==
2FMX is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Cricetulus_griseus Cricetulus griseus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FMX OCA].
 
==Reference==
An open conformation of switch I revealed by Sar1-GDP crystal structure at low Mg2+., Rao Y, Bian C, Yuan C, Li Y, Chen L, Ye X, Huang Z, Huang M, Biochem Biophys Res Commun. 2006 Sep 29;348(3):908-15. Epub 2006 Aug 1. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16899220 16899220]
[[Category: Cricetulus griseus]]
[[Category: Cricetulus griseus]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Bian, C.]]
[[Category: Bian C]]
[[Category: Huang, M.]]
[[Category: Huang M]]
[[Category: Li, Y.]]
[[Category: Li Y]]
[[Category: Rao, Y.]]
[[Category: Rao Y]]
[[Category: Yuan, C.]]
[[Category: Yuan C]]
[[Category: Cop ii assembly]]
[[Category: Crystal structure]]
[[Category: Dimerization]]
[[Category: Sar1]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 14:51:52 2008''

Latest revision as of 16:50, 13 March 2024

An open conformation of switch I revealed by Sar1-GDP crystal structure at low Mg(2+)An open conformation of switch I revealed by Sar1-GDP crystal structure at low Mg(2+)

Structural highlights

2fmx is a 2 chain structure with sequence from Cricetulus griseus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.82Å
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

SAR1B_CRIGR Involved in transport from the endoplasmic reticulum to the Golgi apparatus. Activated by the guanine nucleotide exchange factor PREB. Involved in the selection of the protein cargo and the assembly of the COPII coat complex.[1] [2]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Kuge O, Dascher C, Orci L, Rowe T, Amherdt M, Plutner H, Ravazzola M, Tanigawa G, Rothman JE, Balch WE. Sar1 promotes vesicle budding from the endoplasmic reticulum but not Golgi compartments. J Cell Biol. 1994 Apr;125(1):51-65. PMID:8138575
  2. ↑ Aridor M, Fish KN, Bannykh S, Weissman J, Roberts TH, Lippincott-Schwartz J, Balch WE. The Sar1 GTPase coordinates biosynthetic cargo selection with endoplasmic reticulum export site assembly. J Cell Biol. 2001 Jan 8;152(1):213-29. PMID:11149932

2fmx, resolution 1.82Å

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