2e0t: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-[[Image:2e0t.gif|left|200px]]<br />
-<applet load="2e0t" size="450" color="white" frame="true" align="right" spinBox="true"
-caption="2e0t, resolution 1.67&Aring;" />
-'''Crystal structure of catalytic domain of dual specificity phosphatase 26, MS0830 from Homo sapiens'''<br />
-==About this Structure==
+==Crystal structure of catalytic domain of dual specificity phosphatase 26, MS0830 from Homo sapiens==
-E0T is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Active as [http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2E0T OCA].
+<StructureSection load='2e0t' size='340' side='right'caption='[[2e0t]], [[Resolution|resolution]] 1.67&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2e0t]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E0T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2E0T FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.67&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2e0t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e0t OCA], [https://pdbe.org/2e0t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2e0t RCSB], [https://www.ebi.ac.uk/pdbsum/2e0t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2e0t ProSAT], [https://www.topsan.org/Proteins/RSGI/2e0t TOPSAN]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/DUS26_HUMAN DUS26_HUMAN] Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. Inhibits MAP kinase p38 by dephosphorylating it and inhibits p38-mediated apoptosis in anaplastic thyroid cancer cells. Can also induce activation of MAP kinase p38 and c-Jun N-terminal kinase (JNK).<ref>PMID:15796912</ref> <ref>PMID:16924234</ref> <ref>PMID:17001450</ref> <ref>PMID:16581800</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e0/2e0t_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2e0t ConSurf].
+<div style="clear:both"></div>
+==See Also==
+*[[Dual specificity phosphatase 3D structures|Dual specificity phosphatase 3D structures]]
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Protein-tyrosine-phosphatase]]
+[[Category: Large Structures]]
-[[Category: Single protein]]
+[[Category: Chen L]]
-[[Category: Chen, L.]]
+[[Category: Hori-Takemoto C]]
-[[Category: Hori-Takemoto, C.]]
+[[Category: Kishishita S]]
-[[Category: Kishishita, S.]]
+[[Category: Liu ZJ]]
-[[Category: Liu, Z.J.]]
+[[Category: Murayama K]]
-[[Category: Murayama, K.]]
+[[Category: Shirozu M]]
-[[Category: RSGI, RIKEN.Structural.Genomics/Proteomics.Initiative.]]
+[[Category: Wang BC]]
-[[Category: Shirozu, M.]]
+[[Category: Xie Y]]
-[[Category: Wang, B.C.]]
+[[Category: Yokoyama S]]
-[[Category: Xie, Y.]]
-[[Category: Yokoyama, S.]]
-[[Category: conserved hypothetical protein]]
-[[Category: hydrolase]]
-[[Category: national project on protein structural and functional analyses]]
-[[Category: nppsfa]]
-[[Category: riken structural genomics/proteomics initiative]]
-[[Category: rsgi]]
-[[Category: structural genomics]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 21:41:31 2007''