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[[Image:2dyu.gif|left|200px]]


{{Structure
==Helicobacter pylori formamidase AmiF contains a fine-tuned cysteine-glutamate-lysine catalytic triad==
|PDB= 2dyu |SIZE=350|CAPTION= <scene name='initialview01'>2dyu</scene>, resolution 1.75&Aring;
<StructureSection load='2dyu' size='340' side='right'caption='[[2dyu]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND=  
<table><tr><td colspan='2'>[[2dyu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Helicobacter_pylori_26695 Helicobacter pylori 26695]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DYU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DYU FirstGlance]. <br>
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Formamidase Formamidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.49 3.5.1.49] </span>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75&#8491;</td></tr>
|GENE= amiF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=210 Helicobacter pylori])
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dyu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dyu OCA], [https://pdbe.org/2dyu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dyu RCSB], [https://www.ebi.ac.uk/pdbsum/2dyu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dyu ProSAT]</span></td></tr>
|DOMAIN=
</table>
|RELATEDENTRY=[[2dyv|2DYV]], [[2e2k|2E2K]], [[2e2l|2E2L]]
== Function ==
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dyu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dyu OCA], [http://www.ebi.ac.uk/pdbsum/2dyu PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2dyu RCSB]</span>
[https://www.uniprot.org/uniprot/AMIF_HELPY AMIF_HELPY] Is an aliphatic amidase with a restricted substrate specificity, as it only hydrolyzes formamide. Probably involved in the nitrogen metabolism of H.pylori.<ref>PMID:11359566</ref>
}}
== Evolutionary Conservation ==
 
[[Image:Consurf_key_small.gif|200px|right]]
'''Helicobacter pylori formamidase AmiF contains a fine-tuned cysteine-glutamate-lysine catalytic triad'''
Check<jmol>
 
  <jmolCheckbox>
 
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dy/2dyu_consurf.spt"</scriptWhenChecked>
==About this Structure==
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
2DYU is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DYU OCA].  
    <text>to colour the structure by Evolutionary Conservation</text>
[[Category: Formamidase]]
  </jmolCheckbox>
[[Category: Helicobacter pylori]]
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2dyu ConSurf].
[[Category: Single protein]]
<div style="clear:both"></div>
[[Category: Hung, C L.]]
== References ==
[[Category: Wang, W C.]]
<references/>
[[Category: aliphatic amidase]]
__TOC__
[[Category: amif]]
</StructureSection>
[[Category: catalytic triad]]
[[Category: Helicobacter pylori 26695]]
[[Category: cek]]
[[Category: Large Structures]]
[[Category: formamidase]]
[[Category: Hung CL]]
[[Category: helicobacter pylori]]
[[Category: Wang WC]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:41:24 2008''

Latest revision as of 16:48, 13 March 2024

Helicobacter pylori formamidase AmiF contains a fine-tuned cysteine-glutamate-lysine catalytic triadHelicobacter pylori formamidase AmiF contains a fine-tuned cysteine-glutamate-lysine catalytic triad

Structural highlights

2dyu is a 2 chain structure with sequence from Helicobacter pylori 26695. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.75Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

AMIF_HELPY Is an aliphatic amidase with a restricted substrate specificity, as it only hydrolyzes formamide. Probably involved in the nitrogen metabolism of H.pylori.[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

  1. ↑ Skouloubris S, Labigne A, De Reuse H. The AmiE aliphatic amidase and AmiF formamidase of Helicobacter pylori: natural evolution of two enzyme paralogues. Mol Microbiol. 2001 May;40(3):596-609. PMID:11359566

2dyu, resolution 1.75Å

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