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[[Image:2dsk.jpg|left|200px]]


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==Crystal structure of catalytic domain of hyperthermophilic chitinase from Pyrococcus furiosus==
The line below this paragraph, containing "STRUCTURE_2dsk", creates the "Structure Box" on the page.
<StructureSection load='2dsk' size='340' side='right'caption='[[2dsk]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2dsk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_furiosus Pyrococcus furiosus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DSK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DSK FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
{{STRUCTURE_2dsk|  PDB=2dsk |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dsk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dsk OCA], [https://pdbe.org/2dsk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dsk RCSB], [https://www.ebi.ac.uk/pdbsum/2dsk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dsk ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q8U1H5_PYRFU Q8U1H5_PYRFU]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ds/2dsk_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2dsk ConSurf].
<div style="clear:both"></div>


'''Crystal structure of catalytic domain of hyperthermophilic chitinase from Pyrococcus furiosus'''
==See Also==
 
*[[Chitinase 3D structures|Chitinase 3D structures]]
 
__TOC__
==Overview==
</StructureSection>
The crystal structure of the catalytic domain of a chitinase from the hyperthermophilic archaeon Pyrococcus furiosus (AD2(PF-ChiA)) has been determined at 1.5 A resolution. This is the first structure of the catalytic domain of an archaeal chitinase. The overall structure of AD2(PF-ChiA) is a TIM-barrel fold with a tunnel-like active site that is a common feature of family 18 chitinases. Although the catalytic residues (Asp522, Asp524 and Glu526) are conserved, comparison of the conserved residues and structures with those of other homologous chitinases indicates that the catalytic mechanism of PF-ChiA is different from that of family 18 chitinases.
[[Category: Large Structures]]
 
==About this Structure==
2DSK is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Pyrococcus_furiosus Pyrococcus furiosus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DSK OCA].
 
==Reference==
Structure of the catalytic domain of the hyperthermophilic chitinase from Pyrococcus furiosus., Nakamura T, Mine S, Hagihara Y, Ishikawa K, Uegaki K, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Jan 1;63(Pt, 1):7-11. Epub 2006 Dec 16. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17183162 17183162]
[[Category: Chitinase]]
[[Category: Pyrococcus furiosus]]
[[Category: Pyrococcus furiosus]]
[[Category: Single protein]]
[[Category: Hagihara Y]]
[[Category: Hagihara, Y.]]
[[Category: Ishikawa K]]
[[Category: Ishikawa, K.]]
[[Category: Mine S]]
[[Category: Mine, S.]]
[[Category: Nakamura T]]
[[Category: Nakamura, T.]]
[[Category: Uegaki K]]
[[Category: Uegaki, K.]]
[[Category: Active domain]]
[[Category: Catalytic domain]]
[[Category: Chitinase]]
[[Category: Crystalline chitin]]
[[Category: Tim-barrel]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 01:09:07 2008''

Latest revision as of 16:48, 13 March 2024

Crystal structure of catalytic domain of hyperthermophilic chitinase from Pyrococcus furiosusCrystal structure of catalytic domain of hyperthermophilic chitinase from Pyrococcus furiosus

Structural highlights

2dsk is a 2 chain structure with sequence from Pyrococcus furiosus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.5Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

Q8U1H5_PYRFU

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

2dsk, resolution 1.50Å

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